Fosphenytoin Sodium

Basic Information

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CAS Number

92134-98-0

Molecular Formula

C16H13N2Na2O6P

Molecular Weight

406.24 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Insecticides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

282-288°C

Solubility

H2O: ≥15mg/mL

SMILES

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C1=CC=C(C=C1)C2(C(=O)N(C(=O)N2)COP(=O)([O-])[O-])C3=CC=CC=C3.[Na+].[Na+]

InChI

InChI=1S/C16H15N2O6P.2Na/c19-14-16(12-7-3-1-4-8-12,13-9-5-2-6-10-13)17-15(20)18(14)11-24-25(21,22)23;;/h1-10H,11H2,(H,17,20)(H2,21,22,23);;/q;2*+1/p-2

InChIKey

GQPXYJNXTAFDLT-UHFFFAOYSA-L

LogP

2.69190

Complexity

536

Safety Information

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GHS Hazard Pictograms

H301

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

Toxicity

LD50 in mice, rats (mg/kg): 234, 363 i.v. (Smith)

Synonyms & References

English

Fosphenytoin_Sodium
Fosphenytoin sodium
Fosphenytoin Sodium Hydrate
disodium,(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl phosphate
FOSPENYTOIN
Fosphenytion SodiuM
Fosphenytoin (disodium)
Fosphenytoin disodium salt
Fosphenytoin sodium,
ACC 9653
ACC 9653-010
Cerebyx
CI 982
Pro-Epanutin
5,5-Diphenyl-3-[(phosphonooxy)methyl]-2,4-imidazolidinedione disodium salt
(SP-4-2)-5,5-Diphenyl-3-((phosphonooxy)methyl)-2,4-imidazolidinedione disodium salt
2,4-Imidazolidinedione, 5,5-diphenyl-3-[(phosphonooxy)methyl]-, disodium salt (9CI)
Cetebyx
Disodium (2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl phosphate
Fostoin
Fosphenytoin disodium
(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl dihydrogen phosphate
sodium salt (1:2)
FOSPHENYTOIN SODIUM (USP-RS)
DTXSID1044271
ACC-9653
disodium [2,5-bis(oxidanylidene)-4,4-diphenyl-imidazolidin-1-yl]methyl phosphate
Fosphenytoin sodium [USAN]
Sodium (2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl phosphate
disodium;(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl phosphate
FOSPHENYTOIN SODIUM (USP MONOGRAPH)

MDL Number

MFCD00948765

Customs Code

2933790090

FAQ

What regulatory guidelines apply to Fosphenytoin Sodium (CAS: 92134-98-0)?

Fosphenytoin Sodium (CAS: 92134-98-0) is regulated under the GHS system for hazardous chemicals, with specific classifications for health and environmental hazards. It is also subject to registration under REACH in the European Union, and is governed by FDA and EPA regulations in the United States, ensuring safety, environmental protection, and proper handling in manufacturing and distribution.

Are there alternatives to Fosphenytoin Sodium (CAS: 92134-98-0) in synthesis?

Alternatives to Fosphenytoin Sodium (CAS: 92134-98-0) in synthesis include related anticonvulsants such as phenytoin and other sodium phenylbutyrate derivatives. Common substitute reagents include various salts and precursors used in the synthesis of antiepileptic drugs, which can offer similar or improved therapeutic properties while potentially reducing adverse effects.

What is the market or research trend for Fosphenytoin Sodium (CAS: 92134-98-0)?

The market for Fosphenytoin Sodium (CAS: 92134-98-0) is seeing growth due to its efficacy in treating seizures, particularly in pediatric and adult patients. Research trends include development of its prodrug form for better absorption and reduced side effects, as well as exploring its potential in other neurological conditions. Market dynamics include increasing demand in developing countries and advancements in drug delivery systems.

How should waste containing Fosphenytoin Sodium (CAS: 92134-98-0) be handled?

Waste containing Fosphenytoin Sodium (CAS: 92134-98-0) should be collected in appropriate containers, sealed, and stored separately. For disposal, professional waste management services should be utilized, adhering to local environmental regulations. Incineration is a common method, but care must be taken to ensure proper combustion to minimize environmental impact. Always follow local and international environmental protection guidelines to ensure safe disposal.