Letermovir | CAS No. 917389-32-3

Letermovir

Basic Information

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CAS Number

917389-32-3

Molecular Formula

C29H28F4N4O4

Molecular Weight

572.56 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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COC1=C(C=C(C=C1)C(F)(F)F)N2C(C3=C(C(=CC=C3)F)N=C2N4CCN(CC4)C5=CC(=CC=C5)OC)CC(=O)O

InChI

InChI=1S/C29H28F4N4O4/c1-40-20-6-3-5-19(16-20)35-11-13-36(14-12-35)28-34-27-21(7-4-8-22(27)30)23(17-26(38)39)37(28)24-15-18(29(31,32)33)9-10-25(24)41-2/h3-10,15-16,23H,11-14,17H2,1-2H3,(H,38,39)/t23-/m0/s1

InChIKey

FWYSMLBETOMXAG-QHCPKHFHSA-N

LogP

5.707400000000005

Topological Polar Surface Area

77.84 Å²

Hydrogen Bond Donor/Acceptor

1 / 8

Complexity

931

Synonyms & References

English

Lorglumide
Letermovir
2-[(4S)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-4H-quinazolin-4-yl]acetic acid
AIC246
AIC-246
AIC 246
1H09Y5WO1F
2-((4S)-8-Fluoro-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3-(2-methoxy-5-(trifluoromethyl)phenyl)-4H-quinazolin-4-yl)acetic acid
Prevymis
Letermovir [USAN:INN]
Prevymis (TN)
(S)-{8-fluoro-2-[4-(3-methoxyphenyl)piperazine-1-yl]-3-(2-methoxy-5-trifluoromethylphenyl)-3,4-dihydroquinazoline-4-yl}acetic acid
(4S)-8-Fluoro-3,4-dihydro-2-[4-(3-methoxyphenyl)-1-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-4-quinazolineacetic acid (ACI)
(S)-2-(8-Fluoro-3-(2-methoxy-5-(trifluoromethyl)phenyl)-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3,4-dihydroquinazolin-4-yl)acetic acid
(S)-2-(8-fluoro-3-(2-methoxy-5-(trifluoromethyl)phenyl)-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3,4-dihydroquinazolin-4-yl)acetic acid
NCGC00378936-02
DTXSID40238683
J05AX18
DA-74962
CS-1571
Letermovir(AIC246)
LETERMOVIR [JAN]
EX-A1871
SCHEMBL379403
917389-32-3
HY-15233
letermovirum
s8873
NCGC00378936-01
LETERMOVIR [USAN]
AS-56206

MDL Number

MFCD22572725

FAQ

What is Letermovir (CAS: 917389-32-3)?

Letermovir (CAS: 917389-32-3) is a small-molecule antiviral drug. It is used for the prevention of cytomegalovirus (CMV) disease in patients who are immunocompromised, particularly those undergoing kidney transplantation. Letermovir inhibits the viral DNA polymerase, which is essential for viral replication.

What are the main uses of Letermovir (CAS: 917389-32-3)?

Letermovir (CAS: 917389-32-3) is primarily used for the prophylaxis of CMV disease in immunocompromised patients, especially those undergoing kidney transplantation. It is also used in the treatment of CMV infections where other antiviral drugs are not suitable or have failed.

Is Letermovir (CAS: 917389-32-3) safe?

Letermovir (CAS: 917389-32-3) is generally considered safe when used as directed. However, like all medications, it may cause side effects. Common side effects include headache, nausea, and diarrhea. Patients should consult their healthcare provider if they experience any adverse reactions.

How should Letermovir (CAS: 917389-32-3) be stored?

Letermovir (CAS: 917389-32-3) should be stored at room temperature, between 15°C and 30°C (59°F and 86°F). It should be kept away from direct sunlight and moisture. Store the medication in its original container and protect it from light exposure to maintain its efficacy.