9-Aminocamptothecin

Basic Information

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CAS Number

91421-43-1

Molecular Formula

C20H17N3O4

Molecular Weight

363.37 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Physical State

Powder

Melting Point

>300°C

Boiling Point

819.6℃ at 760 mmHg

Density

1.55

Flash Point

449.5 °C

Solubility

N/A

Refractive Index

1.771

SMILES

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CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC=C5N=C4C3=C2)N)O

InChI

InChI=1S/C20H17N3O4/c1-2-20(26)13-7-16-17-10(6-11-14(21)4-3-5-15(11)22-17)8-23(16)18(24)12(13)9-27-19(20)25/h3-7,26H,2,8-9,21H2,1H3/t20-/m0/s1

InChIKey

FUXVKZWTXQUGMW-FQEVSTJZSA-N

LogP

1.6617999999999995

Topological Polar Surface Area

107.44 Å²

Hydrogen Bond Donor/Acceptor

3 / 7

Complexity

775

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Storage Conditions

2-8℃

Synonyms & References

English

(S)-10-Amino-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
9-Amino-20-(S)-camptothecin
10-Amino-4(S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
9-Aminocamptothecin
(S)-10-Amino-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
CAMPTOTHECIN, 9-AMINO-(RG)
(20S)-9-aminocamptothecin
9-AC
9-AMINO-20(S)-CAMPTOTHECIN
9-Amino-20-camptothecin
9-Amino-camptothecin
Camptothecin,9-amino
Camptothecin, 9-amino-
9-Amino-cpt
NSC603071
5MB77ICE2Q
9-Nitro-CPT
(S)-10-Amino-4-ethyl-4-hydroxy-1H-pyrano(3
(S)-10-Amino-4-ethyl-4-hydroxy-1H-pyrano(3;,4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione
,4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione
,4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 10-amino-4-ethyl-4-hydroxy-, (S)-
10-amino-4(S)-4-ethyl-4-hydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione
10-Aminocamptothecin
1H-Pyrano(3
1H-Pyrano(3;,4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 10-amino-4-ethyl-4-hydroxy-, (S)-
9-amino Camptothecin
9-NH2-Camptothecin
Aminocamptothecin
MLS000728575
SMR000445687
(4S)-10-Amino-4-ethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione (ACI)

MDL Number

MFCD00909855

Customs Code

2934999090

FAQ

What is 9-Aminocamptothecin (CAS: 91421-43-1)?

9-Aminocamptothecin is a semi-synthetic derivative of camptothecin. It has a molecular formula of C26H29N5O7. This compound exhibits potent antitumor activity and is used in cancer chemotherapy.

What are the main uses of 9-Aminocamptothecin (CAS: 91421-43-1)?

9-Aminocamptothecin is primarily used as an antitumor agent in cancer chemotherapy. It is also studied for its potential in the development of new anticancer drugs.

Is 9-Aminocamptothecin (CAS: 91421-43-1) safe?

9-Aminocamptothecin can be toxic and should be handled with caution. It may cause nausea, vomiting, and bone marrow suppression. Adequate protective measures, including gloves and respiratory protection, are recommended. Storage in a cool, dry place away from light is necessary.

How should 9-Aminocamptothecin (CAS: 91421-43-1) be stored?

9-Aminocamptothecin should be stored in a tightly sealed container at room temperature (preferably 15-25°C) and protected from light. It should be kept away from heat and moisture to ensure stability and prevent degradation.