2-Fluorophenethyl bromide

Basic Information

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CAS Number

91319-54-9

Molecular Formula

C8H8BrF

Molecular Weight

203.05 g/mol

Chemical Classification

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

Colorless to Yellow Liquid

Boiling Point

73-75 °C/20 mmHg

Density

1.4458 g/mL at 25 °C

Refractive Index

n20/D 1.5340(lit.)

SMILES

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C1=CC=C(C(=C1)CCBr)F

InChI

InChI=1S/C8H8BrF/c9-6-5-7-3-1-2-4-8(7)10/h1-4H,5-6H2

InChIKey

FQGDFWIQBCQXPS-UHFFFAOYSA-N

LogP

2.7631000000000014

Topological Polar Surface Area

0.0 Å²

Hydrogen Bond Donor/Acceptor

0 / 0

Complexity

95.3

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

1-(2-Bromoethyl)-2-fluorobenzene
1-(2-Bromo-ethyl)-2-fluoro-benzene
2-FLUORO PHENETHYL BROMIDE
2-Fluorophenethyl bromide
1-(2-Bromoethyl)-2-fluorobenzene (ACI)
2-(2-Fluorophenyl)ethyl bromide
CS-0139578
1-(2-bromoethyl)-2-fluorobenzene
2-Fluorophenethyl bromide, 97%
2-(2-fluorophenyl)-ethylbromide
DTXSID00373660
1-(2-bromoethyl)-2-fluoro-benzene
2-Fluorophenethylbromide
AKOS000301913
MFCD04117466
2-fluorophenyl-ethylbromide
SCHEMBL459369
Benzene, 1-(2-bromoethyl)-2-fluoro-
EN300-675175
BBL102064
1-(2-Bromo-ethyl)-2-fluorobenzene
2-fluorophenyl ethyl bromide
SY060877
91319-54-9
STL555863
FS-5427
DB-015896

MDL Number

MFCD04117466

Customs Code

2903999090

FAQ

What are the physical and chemical properties of 2-Fluorophenethyl bromide (CAS: 91319-54-9)?

2-Fluorophenethyl bromide is a colorless or white crystalline solid with a molecular weight of approximately 217.03 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and chloroform. This compound is moderately reactive, especially in the presence of nucleophiles. It is typically used in organic synthesis as a fluorinated aromatic intermediate.

How is 2-Fluorophenethyl bromide (CAS: 91319-54-9) typically synthesized?

2-Fluorophenethyl bromide is synthesized via the reaction of 2-phenylethanol with phosphorus tribromide in the presence of a catalytic amount of triethylamine. The reaction is carried out at room temperature and provides good selectivity and yield, making it a common method for preparing this compound.

What industries use 2-Fluorophenethyl bromide (CAS: 91319-54-9)?

2-Fluorophenethyl bromide is primarily used in the pharmaceutical and polymer industries. It serves as a key intermediate for the synthesis of various fluorinated compounds, which are used in drug development and as monomers for fluoroelastomers and other advanced polymers. It also finds applications in the development of sensors and semiconductors.

What precautions should be taken when handling 2-Fluorophenethyl bromide (CAS: 91319-54-9)?

When handling 2-Fluorophenethyl bromide, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be carefully cleaned up using appropriate absorbent materials, and the area should be well flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.