Veliparib | CAS No. 912444-00-9

Veliparib

Basic Information

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CAS Number

912444-00-9

Molecular Formula

C13H16N4O

Molecular Weight

244.3 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Boiling Point

579.023°C at 760 mmHg

Density

1.274

SMILES

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CC1(CCCN1)C2=NC3=C(C=CC=C3N2)C(=O)N

InChI

InChI=1S/C13H16N4O/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17)/t13-/m1/s1

InChIKey

JNAHVYVRKWKWKQ-CYBMUJFWSA-N

LogP

1.2603999999999997

Topological Polar Surface Area

83.80000000000001 Å²

Hydrogen Bond Donor/Acceptor

4 / 5

Complexity

348

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

1H-Benzimidazole-7-carboxamide,2-[(2R)-2-methyl-2-pyrrolidinyl]-
ABT 888
Veliparib
(R)-2-(2-Methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-4-carboxamide
(R)-2-(2-Methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-7-carboxamide
2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide
2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-7-carboxamide
2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide
ABT-888
ABT-888 Veliparib
ABT-888 (Veliparib)
Veliparib (ABT-888)
Veliparib (ABT-888,NSC 737664)
(R)-1-Boc-2-piperidineacetic acid
(R)-2-(1-(tert-butoxycarbonyl)piperidin-2-yl) acetic acid
(R)-N-Boc-2-piperidine acetic acid
2-[(2R)-1-(tert-butoxycarbonyl)hexahydro-2-pyridinyl]acetic acid
ABT888
2-[(2R)-2-methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide
01O4K0631N
2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4-
(2r)-2-(7-Carbamoyl-1h-Benzimidazol-2-Yl)-2-Methylpyrrolidinium
2-
1H-Benzimidazole-4-carboxamide, 2-[(2R)-2-methyl-2-pyrrolidinyl]- (9CI)
2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide (ACI)
2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-1,3-benzodiazole-4-carboxamide
2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide
A 861695
Veliparib ER
(R)-2-(2-Methylpyrrolidin-2-yl)-1H-benimidazole-4-carboxamide (VELIPARIB)
UNII-01O4K0631N

MDL Number

MFCD16661059

Customs Code

2934999090

FAQ

What is Veliparib (CAS: 912444-00-9)?

Veliparib (CAS: 912444-00-9) is an oral poly(ADP-ribose) polymerase (PARP) inhibitor, commonly used in the treatment of certain types of cancer. It works by blocking the activity of PARP enzymes, which are involved in DNA repair processes.

What are the main uses of Veliparib (CAS: 912444-00-9)?

Veliparib (CAS: 912444-00-9) is primarily used in the treatment of advanced or recurrent solid tumors, including ovarian cancer and small cell lung cancer. It is also used in combination therapy with other drugs.

Is Veliparib (CAS: 912444-00-9) safe?

Veliparib (CAS: 912444-00-9) is generally considered safe when used as prescribed. However, it may cause side effects such as nausea, vomiting, and fatigue. It is important to follow the instructions provided by healthcare professionals and take necessary precautions to avoid adverse reactions.

How should Veliparib (CAS: 912444-00-9) be stored?

Veliparib (CAS: 912444-00-9) should be stored at a temperature not exceeding 25°C (77°F) and protected from light. Keep it in a tightly closed container and out of reach of children. It is advisable to store it in a cool, dry place away from direct sunlight and heat sources.