Gemigliptin | CAS No. 911637-19-9

Gemigliptin

Basic Information

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CAS Number

911637-19-9

Molecular Formula

C18H19F8N5O2

Molecular Weight

489.37 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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C1CC(CN(C1=O)CC(CC(=O)N2CCC3=C(C2)N=C(N=C3C(F)(F)F)C(F)(F)F)N)(F)F

InChI

InChI=1S/C18H19F8N5O2/c19-16(20)3-1-12(32)31(8-16)6-9(27)5-13(33)30-4-2-10-11(7-30)28-15(18(24,25)26)29-14(10)17(21,22)23/h9H,1-8,27H2/t9-/m0/s1

InChIKey

ZWPRRQZNBDYKLH-VIFPVBQESA-N

LogP

2.3740000000000006

Topological Polar Surface Area

92.42 Å²

Hydrogen Bond Donor/Acceptor

2 / 7

Complexity

746

Synonyms & References

English

GeMigliptin
1-[(2S)-2-amino-4-[2,4-bis(trifluoromethyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]-4-oxobutyl]-5,5-difluoropiperidin-2-one
Gemigliptin Hydrochloride
Gemigliptin Tartarate
1-[(2S)-2-Amino-4-[5,8-dihydro-2,4-bis(trifluoromethyl)pyrido[3,4-d]pyrimidin-7(6H)-yl]-4-oxobutyl]-5,5-difluoro-2-piperidinone (ACI)
Pyrido[3,4-d]pyrimidine, 7-[(3S)-3-amino-4-(5,5-difluoro-2-oxo-1-piperidinyl)-1-oxobutyl]-5,6,7,8-tetrahydro-2,4-bis(trifluoromethyl)- (9CI)
1-[(2S)-2-Amino-4-[2,4-bis(trifluoromethyl)-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl]-4-oxobutyl]-5,5-difluoropiperidin-2-one
1-[(2S)-2-Amino-4-[2,4-bis(trifluoromethyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]-4-oxobutyl]-5,5-difluoropiperidin-2-one
Gemigliptin
Zemiglo
911637-19-9
GEMIGLIPTIN [WHO-DD]
5DHU18M5D6
LC-15-0444
GLXC-15788
AKOS025290873
(S)-1-(2-amino-4-(2,4-bis(trifluoromethyl)-5,8- dihydropyrido[3,4-d]pyrimidin-7(6H)-yl)-4- oxobutyl)-5,5-difluoropiperidin-2-one (Gemigliptin)
1-((2S)-2-Amino-4-(2,4-bis(trifluoromethyl)-5,8-dihydropyrido(3,4-d)pyrimidin-7(6H)-yl)-4-oxobutyl-5,5-difluoropiperidin-2-one
911637-19-9 (free base)
EX-A8802
DA-73692
UNII-5DHU18M5D6
BDBM664710
NS00072914
AS-75936
D10502
CS-0003618
CHEMBL3707235
Gemigliptin [INN]
ZWPRRQZNBDYKLH-VIFPVBQESA-N
(S)-1-(2-amino-4-(2,4-bis(trifluoromethyl)-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl)-4-oxobutyl)-5,5-difluoropiperidin-2-one

MDL Number

MFCD19443742

FAQ

What regulatory guidelines apply to Gemigliptin (CAS: 911637-19-9)?

Gemigliptin (CAS: 911637-19-9) is subject to various regulatory guidelines including the Globally Harmonized System (GHS) for classification and labeling of chemicals, REACH regulations in the European Union, and FDA/EPA requirements for pharmaceuticals and environmental safety. Companies handling or manufacturing this compound should ensure compliance with these regulations and local laws.

Are there alternatives to Gemigliptin (CAS: 911637-19-9) in synthesis?

Alternatives to Gemigliptin (CAS: 911637-19-9) in synthesis include other dipeptidyl peptidase-4 (DPP-4) inhibitors such as sitagliptin and vildagliptin, which can serve as effective substitutes. These alternatives may offer similar pharmacological profiles and can be used based on specific requirements and availability.

What is the market or research trend for Gemigliptin (CAS: 911637-19-9)?

The market for Gemigliptin (CAS: 911637-19-9) is influenced by research trends in diabetes management, where there is a focus on safer and more effective DPP-4 inhibitors. Future trends may include the development of new formulations and combinations to enhance efficacy and reduce side effects. Market demand is expected to remain stable with ongoing clinical evaluations and regulatory approvals.

How should waste containing Gemigliptin (CAS: 911637-19-9) be handled?

Waste containing Gemigliptin (CAS: 911637-19-9) should be collected and disposed of according to local environmental protection regulations. Incineration or professional waste disposal services are recommended to ensure proper treatment and minimize environmental impact. Companies should also follow safe handling and storage practices to prevent contamination and ensure compliance with regulatory standards.