Arginyl-glycyl-aspartyl-serine

Basic Information

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CAS Number

91037-65-9

Molecular Formula

C15H27N7O8

Molecular Weight

433.42 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

183-187 ºC

Boiling Point

°Cat760mmHg

Density

1.65±0.1 g/cm3 (20 ºC 760 Torr),

Water Solubility

Soluble in water at 1mg/ml

Refractive Index

1.659

SMILES

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C(CC(C(=O)NCC(=O)NC(CC(=O)O)C(=O)NC(CO)C(=O)O)N)CN=C(N)N

InChI

InChI=1S/C15H27N7O8/c16-7(2-1-3-19-15(17)18)12(27)20-5-10(24)21-8(4-11(25)26)13(28)22-9(6-23)14(29)30/h7-9,23H,1-6,16H2,(H,20,27)(H,21,24)(H,22,28)(H,25,26)(H,29,30)(H4,17,18,19)/t7-,8-,9-/m0/s1

InChIKey

NNRFRJQMBSBXGO-CIUDSAMLSA-N

LogP

-4.995300000000002

Topological Polar Surface Area

272.55 Å²

Hydrogen Bond Donor/Acceptor

12 / 15

Complexity

665

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

L-Serine,L-arginylglycyl-L-a-aspartyl-
Arg-Gly-Asp-Ser
arginyl-glycyl-aspartyl-serine
H-Arg-Gly-Asp-Ser-OH
RGDS
RGDS peptide
2ACOH 2H2O
Arg-Gly-Asp-Ser-OH
fibronectin active fragment
FIBRONECTIN INHIBITOR
L-ARG-GLY-ASP-SER
L-Arg-Gly-L-Asp-L-Ser-OH
RGDS 1
Palmitoyl Oligopertide
Fibronectin tetrapeptide
C15H27N7O8
L-Arginylglycyl-L-alpha-aspartyl-L-serine
L-Serine, L-arginylglycyl-L-alpha-aspartyl-
L-Serine, N-(N-(N-L-arginylglycyl)-L-alpha-aspartyl)-
AK163508
3-[(S)-2-((S)-2-Amino-5-guanidino-pentanoylamino)-acetylamino]-N-(1-carboxy-2-hydroxy-ethyl)-succinamic acid
BDBM50241180
3450AH
AKO
L-Arginylglycyl-L-α-aspartyl-L-serine (ACI)
L-Serine, N-[N-(N-L-arginylglycyl)-L-α-aspartyl]- (ZCI)
102: PN: WO2008113030 SEQID: 103 unclaimed sequence
10: PN: JP2003089648 SEQID: 11 unclaimed
10: PN: WO03099465 SEQID: 11 claimed protein
10: PN: WO2020081717 SEQID: 10 claimed protein
110: PN: US20100136614 SEQID: 111 unclaimed sequence

MDL Number

MFCD00076452

FAQ

What are the physical and chemical properties of Arginyl-glycyl-aspartyl-serine (CAS: 91037-65-9)?

Arginyl-glycyl-aspartyl-serine is a tetrapeptide with a molecular weight of approximately 447.44 g/mol. It is soluble in water but poorly soluble in organic solvents. The compound crystallizes in the form of a white solid. It is relatively stable under normal conditions but is sensitive to strong acids and bases, making it prone to hydrolysis.

How is Arginyl-glycyl-aspartyl-serine (CAS: 91037-65-9) typically synthesized?

Arginyl-glycyl-aspartyl-serine is typically synthesized via solid-phase peptide synthesis (SPPS) using standard Fmoc chemistry. The reaction involves coupling protected amino acids sequentially, followed by deprotection and purification steps. The yield is generally good, and the product is obtained with high purity.

What industries use Arginyl-glycyl-aspartyl-serine (CAS: 91037-65-9)?

Arginyl-glycyl-aspartyl-serine is used in various industries, including pharmaceuticals, as a synthetic peptide for research and drug development. It is also utilized in the production of peptide-based sensors and in the field of biotechnology for its specific binding properties and potential applications in diagnostic tools.

What precautions should be taken when handling Arginyl-glycyl-aspartyl-serine (CAS: 91037-65-9)?

When handling Arginyl-glycyl-aspartyl-serine, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up using a suitable absorbent material and disposed of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS/SDS) for detailed safety information and emergency procedures.