alpha-CGRP (human)

Basic Information

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CAS Number

90954-53-3

Molecular Formula

C163H267N51O49S2

Molecular Weight

3789.31 g/mol

Basic Physical Properties

Water Solubility

Soluble in water or 1% acetic acid at 1mg/ml.

SMILES

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CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)CNC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC4=CN=CN4)NC(=O)C(C(C)O)NC(=O)C(C(C)C)NC(=O)C(CS)NC(=O)C(C(C)O)NC(=O)C(C)NC(=O)C(C(C)O)NC(=O)C(CC(=O)O)NC(=O)C(CS)NC(=O)C(C)N

InChI

InChI=1S/C163H269N51O49S2/c1-73(2)52-97(186-116(226)65-179-131(233)82(18)183-139(241)98(53-74(3)4)193-137(239)94(44-35-49-176-162(171)172)188-142(244)101(57-91-62-175-72-182-91)199-159(261)128(88(24)221)213-156(258)123(79(13)14)207-151(253)110(71-265)204-160(262)126(86(22)219)210-133(235)84(20)185-157(259)125(85(21)218)211-147(249)105(61-119(229)230)198-150(252)109(70-264)203-130(232)81(17)166)140(242)194-99(54-75(5)6)141(243)202-108(69-217)149(251)190-95(45-36-50-177-163(173)174)138(240)201-106(67-215)134(236)180-63-115(225)178-64-118(228)205-121(77(9)10)155(257)208-122(78(11)12)154(256)191-93(43-32-34-48-165)136(238)196-102(58-112(167)222)144(246)197-103(59-113(168)223)143(245)195-100(56-90-40-29-26-30-41-90)145(247)209-124(80(15)16)161(263)214-51-37-46-111(214)152(254)212-127(87(23)220)158(260)200-104(60-114(169)224)146(248)206-120(76(7)8)153(255)181-66-117(227)187-107(68-216)148(250)189-92(42-31-33-47-164)135(237)184-83(19)132(234)192-96(129(170)231)55-89-38-27-25-28-39-89/h25-30,38-41,62,72-88,92-111,120-128,215-221,264-265H,31-37,42-61,63-71,164-166H2,1-24H3,(H2,167,222)(H2,168,223)(H2,169,224)(H2,170,231)(H,175,182)(H,178,225)(H,179,233)(H,180,236)(H,181,255)(H,183,241)(H,184,237)(H,185,259)(H,186,226)(H,187,227)(H,188,244)(H,189,250)(H,190,251)(H,191,256)(H,192,234)(H,193,239)(H,194,242)(H,195,245)(H,196,238)(H,197,246)(H,198,252)(H,199,261)(H,200,260)(H,201,240)(H,202,243)(H,203,232)(H,204,262)(H,205,228)(H,206,248)(H,207,253)(H,208,257)(H,209,247)(H,210,235)(H,211,249)(H,212,254)(H,213,258)(H,229,230)(H4,171,172,176)(H4,173,174,177)/t81-,82-,83-,84-,85+,86+,87+,88+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-,124-,125-,126-,127-,128-/m0/s1

InChIKey

DNKYDHSONDSTNJ-XJVRLEFXSA-N

Complexity

8970

Synonyms & References

English

ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2
ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2 (DISULFIDE BRIDGE: 2-7)
CalcitoninGeneRelatedPeptidehuMan,CalcitoninGeneRelatedPeptidehuMa
Human calcitonin gene-related peptide 1
α-CGRP (human)|Calcitonin Gene Related Peptide II, human
ALPHA-CGRP (HUMAN)
ALPHA-CGRP (HUMAN) TRIFLUOROACETATE SALT
Alpha-CGRP (human) trifluoroacetate salt H-Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2 trifluoroacetate salt (Disulfide bond)
a-Calcitonin gene-related peptide(human)
Calcitonin Gene Related Peptide human
CGRP (Human)
α-CGRP (human)
α-CGRP (human), CGRP-I (human)
ALA-CYS-ASN-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-MET-VAL-LYS-SER-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2(DISULFIDE BRIDGE CYS2-CYS7)
ALA-CYS-ASP-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2
Calcitonin Gene Rela
Calcitonin Gene Related Peptide II, human
alpha-Calcitonin gene-related peptide (human)
1,2-Dithia-5,8,11,14,17-pentaazacycloeicosane, cyclic peptide deriv.
Human CGRP
Human CGRP-α
Human alpha calcitonin gene-related peptide
Human calcitonin gene-related peptide I
Human α-CGRP
Human α-calcitonin gene-related peptide
α-Calcitonin gene-related peptide (human reduced), cyclic (2→7)-disulfide
α-CGRP(human)
90954-53-3
Human CGRP-alpha
G12583
DA-79157

MDL Number

MFCD00285485

FAQ

What is alpha-CGRP (human) (CAS: 90954-53-3)?

Alpha-CGRP (human) (CAS: 90954-53-3) is a peptide that is a potent agonist of the calcitonin gene-related peptide receptor. It is known for its role in pain modulation and vasodilation. The compound has a molecular formula of C32H47N7O5 and is a key molecule in the study of cardiovascular and neurological conditions.

What are the main uses of alpha-CGRP (human) (CAS: 90954-53-3)?

Alpha-CGRP (human) (CAS: 90954-53-3) is primarily used in research and pharmaceutical applications. It is an important tool for studying pain pathways and cardiovascular diseases. Its role in therapeutic development for migraine and other pain conditions is also being explored.

Is alpha-CGRP (human) (CAS: 90954-53-3) safe?

Alpha-CGRP (human) (CAS: 90954-53-3) is generally considered safe for research and pharmaceutical use when handled properly. However, it should be stored away from direct sunlight and kept in a cool, dry place. Protective gloves and proper ventilation are recommended during handling to avoid skin contact and inhalation.

How should alpha-CGRP (human) (CAS: 90954-53-3) be stored?

Alpha-CGRP (human) (CAS: 90954-53-3) should be stored in a cool, dry place, preferably at a temperature between 2-8°C (36-46°F). It should be protected from direct sunlight and kept in a tightly sealed container to maintain its potency and stability. Proper storage conditions are crucial to ensure the compound remains effective for research and clinical use.