2-Methoxypyrimidine-5-carbaldehyde

Basic Information

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CAS Number

90905-32-1

Molecular Formula

C6H6N2O2

Molecular Weight

138.13 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Aldehydes

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

94-96°C

Boiling Point

281.2℃ at 760 mmHg

Density

1.238

Flash Point

123.9°C

SMILES

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COC1=NC=C(C=N1)C=O

InChI

InChI=1S/C6H6N2O2/c1-10-6-7-2-5(4-9)3-8-6/h2-4H,1H3

InChIKey

MERUNNHMVZFFRE-UHFFFAOYSA-N

LogP

0.29769999999999985

Topological Polar Surface Area

52.08 Å²

Hydrogen Bond Donor/Acceptor

0 / 4

Complexity

110

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

2-Methoxypyrimidine-5-carbaldehyde
2-Methoxy-5-pyrimidinecarbaldehyde
2-Methoxy-pyrimidine-5-carbaldehyde
5-FORMYL-2-METHOXYPYRIMIDINE
5-Pyrimidinecarboxaldehyde,2-methoxy-
5-PYRIMIDINECARBOXALDEHYDE, 2-METHOXY-
2-Methoxypyrimidine-5-carboxaldehyde
PubChem5296
MERUNNHMVZFFRE-UHFFFAOYSA-N
SBB018979
STK731765
2-Methoxy-pyrimidine-5-carboxaldehyde
AB15446
TRA0089298
HC210383
EN001140
SY022439
2-Methoxy-5-pyrimidinecarboxaldehyde (ACI)
2-methoxypyrimidine-5-carbaldehyde
90905-32-1
W-204044
DB-002461
2-METHOXY-5-PYRIMIDINECARBALDEHYDE
SCHEMBL1133947
MFCD03446732
EN300-75114
AC-5039
Z274574980
PS-4524
CS-W003085
AKOS000283889

MDL Number

MFCD03446732

Customs Code

2933599090

FAQ

What are the physical and chemical properties of 2-Methoxypyrimidine-5-carbaldehyde (CAS: 90905-32-1)?

2-Methoxypyrimidine-5-carbaldehyde (CAS: 90905-32-1) is a crystalline solid with a molecular weight of approximately 158.14 g/mol. It has a low solubility in water but is soluble in organic solvents like ethanol and acetone. This compound is reactive and can undergo electrophilic aromatic substitution reactions. It is often used in organic synthesis due to its reactivity and functional groups.

How is 2-Methoxypyrimidine-5-carbaldehyde (CAS: 90905-32-1) typically synthesized?

2-Methoxypyrimidine-5-carbaldehyde (CAS: 90905-32-1) is typically synthesized by the reaction of 2-chloro-5-methoxypyrimidine with sodium hydroxide, followed by oxidation. This method provides good yield and selectivity. Other methods include the direct oxidation of 2-methoxypyrimidine with potassium permanganate in the presence of sulfuric acid.

What industries use 2-Methoxypyrimidine-5-carbaldehyde (CAS: 90905-32-1)?

2-Methoxypyrimidine-5-carbaldehyde (CAS: 90905-32-1) is used in the pharmaceutical industry for the synthesis of various drugs, particularly those targeting DNA and RNA. It is also utilized in the polymer industry for developing new materials, and in the sensor and semiconductor industries for specific chemical detection and device fabrication.

What precautions should be taken when handling 2-Methoxypyrimidine-5-carbaldehyde (CAS: 90905-32-1)?

When handling 2-Methoxypyrimidine-5-carbaldehyde (CAS: 90905-32-1), it is essential to wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Work should be conducted in a fume hood to avoid inhalation. Spills should be cleaned up using absorbent materials and disposed of according to local hazardous waste regulations. Always refer to the safety data sheet (SDS) for detailed handling and storage instructions.