2-Methoxypyrimidine-5-carbaldehyde(CAS: 90905-32-1)

2-Methoxypyrimidine-5-carbaldehyde (CAS: 90905-32-1) is a crystalline solid with a molecular weight of approximately 158.14 g/mol. It has a low solubility in water but is soluble in organic solvents like ethanol and acetone. This compound is reactive and can undergo electrophilic aromatic substitution reactions. It is often used in organic synthesis due to its reactivity and functional groups.

2-Methoxypyrimidine-5-carbaldehyde (CAS: 90905-32-1) is typically synthesized by the reaction of 2-chloro-5-methoxypyrimidine with sodium hydroxide, followed by oxidation. This method provides good yield and selectivity. Other methods include the direct oxidation of 2-methoxypyrimidine with potassium permanganate in the presence of sulfuric acid.

2-Methoxypyrimidine-5-carbaldehyde (CAS: 90905-32-1) is used in the pharmaceutical industry for the synthesis of various drugs, particularly those targeting DNA and RNA. It is also utilized in the polymer industry for developing new materials, and in the sensor and semiconductor industries for specific chemical detection and device fabrication.

When handling 2-Methoxypyrimidine-5-carbaldehyde (CAS: 90905-32-1), it is essential to wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Work should be conducted in a fume hood to avoid inhalation. Spills should be cleaned up using absorbent materials and disposed of according to local hazardous waste regulations. Always refer to the safety data sheet (SDS) for detailed handling and storage instructions.