tert-butyl (3R,4R)-4-amino-3-fluoropiperidine-1-carboxylate

Basic Information

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CAS Number

907544-16-5

Molecular Formula

C10H19FN2O2

Molecular Weight

436.54 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Basic Physical Properties

Boiling Point

285.6°C at 760 mmHg

Density

1.11

Flash Point

126.5°C

Refractive Index

1.481

SMILES

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CC(C)(C)OC(=O)N1CCC(C(C1)F)N

InChI

InChI=1S/C10H19FN2O2/c1-10(2,3)15-9(14)13-5-4-8(12)7(11)6-13/h7-8H,4-6,12H2,1-3H3/t7-,8-/m0/s1

InChIKey

ZQRYPCAUVKVMLZ-YUMQZZPRSA-N

LogP

1.93080

Complexity

240

Synonyms & References

English

(3R,4R)-tert-Butyl 4-amino-3-fluoropiperidine-1-carboxylate
tert-butyl 3,4-trans-4-amino-3-fluoropiperidine-1-carboxylate racemate
1-Piperidinecarboxylic acid, 4-amino-3-fluoro-, 1,1-dimethylethyl ester, (3R,4R)-rel-
trans-tert-butyl 4-amino-3-fluoropiperidine-1-carboxylate
rel-1,1-Dimethylethyl (3R,4R)-4-amino-3-fluoro-1-piperidinecarboxylate (ACI)
tert-Butyl trans-4-amino-3-fluoropiperidine-1-carboxylate
trans-4-Amino-3-fluoropiperidine-1-carboxylic acid tert-butyl ester
trans-tert-Butyl 4-amino-3-fluoropiperidine-1-carboxylate
tert-butyl trans-4-amino-3-fluoropiperidine-1-carboxylate
trans-4-Amino-3-fluoro-piperidine-1-carboxylic acid tert-butyl ester
tert-butyl (3R,4R)-4-amino-3-fluoropiperidine-1-carboxylate
EN300-7063604
(3R,4R)-4-Amino-1-Boc-3-fluoropiperidine
ZQRYPCAUVKVMLZ-HTQZYQBOSA-N
(3R,4R) tert-butyl 4-amino-3-fluoropiperidine-1-carboxylate
tert-butyl trans(+/-)-4-amino-3-fluoropiperidine-1-carboxylate
1-Piperidinecarboxylic acid, 4-amino-3-fluoro-, 1,1-dimethylethyl ester, (3R,4R)-
(3R,4R)-tert-butyl 4-amino-3-fluoropiperidine-1-carboxylate
trans-(3R,4R)-1-Boc-4-amino-3-fluoropiperidine
(3R,4R)-4-Amino-1-Boc-3-fluoropiperidine, AldrichCPR
DTXSID00670500
(3R,4R)tert-butyl 4-amino-3-fluoropiperidine-1-carboxylate
AKOS015897995
(3R,4R)-tert-butyl4-amino-3-fluoropiperidine-1-carboxylate
AS-33786
rac-tert-butyl (3R,4R)-4-amino-3-fluoropiperidine-1-carboxylate
1260612-08-5
CS-0058589
MFCD12756122
MFCD18791211
907544-16-5

MDL Number

MFCD18791211

FAQ

What regulatory guidelines apply to tert-butyl (3R,4R)-4-amino-3-fluoropiperidine-1-carboxylate (CAS: 907544-16-5)?

Tert-butyl (3R,4R)-4-amino-3-fluoropiperidine-1-carboxylate (CAS: 907544-16-5) must comply with various regulatory guidelines. Under the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), it should be classified according to its physical and chemical properties, and appropriate hazard communication labels should be used. In the European Union, it falls under the Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH) regulations, requiring detailed safety data sheets (SDS) and potential authorization for certain uses. Additionally, in the United States, the Food and Drug Administration (FDA) and Environmental Protection Agency (EPA) have specific requirements for the handling, storage, and disposal of this compound to ensure public health and environmental safety.

Are there alternatives to tert-butyl (3R,4R)-4-amino-3-fluoropiperidine-1-carboxylate (CAS: 907544-16-5) in synthesis?

There are alternative reagents that can be used in place of tert-butyl (3R,4R)-4-amino-3-fluoropiperidine-1-carboxylate (CAS: 907544-16-5) depending on the specific synthetic route. For instance, (3R,4R)-4-amino-3-fluoropiperidine-1-carboxylic acid or its corresponding alkyl esters might be viable alternatives. The choice of alternative reagents depends on the desired product, reaction conditions, and the need to avoid certain toxic or hazardous materials. It is essential to evaluate each alternative for its effectiveness and safety in the context of the overall synthetic process.

What is the market or research trend for tert-butyl (3R,4R)-4-amino-3-fluoropiperidine-1-carboxylate (CAS: 907544-16-5)?

Tert-butyl (3R,4R)-4-amino-3-fluoropiperidine-1-carboxylate (CAS: 907544-16-5) is currently experiencing a growing interest in both academic and industrial research due to its potential applications in medicinal chemistry and pharmaceuticals. Research trends include its use as a precursor in the synthesis of complex molecules, particularly for the development of new drug candidates. Market trends indicate increasing demand in the pharmaceutical industry, driven by the need for innovative and effective therapeutic agents. However, the market remains niche, with ongoing efforts to explore its full potential and regulatory challenges that must be addressed.

How should waste containing tert-butyl (3R,4R)-4-amino-3-fluoropiperidine-1-carboxylate (CAS: 907544-16-5) be handled?

Waste containing tert-butyl (3R,4R)-4-amino-3-fluoropiperidine-1-carboxylate (CAS: 907544-16-5) should be managed with strict adherence to environmental protection guidelines. Waste liquid should be collected in appropriate containers and stored in a secure location. For solid waste, it is advisable to incinerate it, which can be done at an authorized facility. Professional waste disposal services should be utilized to ensure compliance with local regulations. Environmental protection precautions include proper labeling of waste containers, ensuring no spillage, and following all safety protocols to prevent environmental contamination. It is crucial to verify that the disposal method aligns with the latest regulatory requirements and safety standards.