Tuftsin | CAS No. 9063-57-4

Tuftsin

Basic Information

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CAS Number

9063-57-4

Molecular Formula

C21H40N8O6

Molecular Weight

500.6 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CC(C(C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(CCCN=C(N)N)C(=O)O)N)O

InChI

InChI=1S/C21H40N8O6/c1-12(30)16(23)18(32)27-13(6-2-3-9-22)19(33)29-11-5-8-15(29)17(31)28-14(20(34)35)7-4-10-26-21(24)25/h12-16,30H,2-11,22-23H2,1H3,(H,27,32)(H,28,31)(H,34,35)(H4,24,25,26)/t12-,13+,14+,15+,16+/m1/s1

InChIKey

IESDGNYHXIOKRW-YXMSTPNBSA-N

LogP

-3.0776999999999974

Topological Polar Surface Area

252.48 Å²

Hydrogen Bond Donor/Acceptor

12 / 14

Complexity

760

Synonyms & References

English

L-Arginine,L-threonyl-L-lysyl-L-prolyl-
TUFTSIN
Tuftsin Tuftsin acetate salt hydrate
H-Thr-Lys-Pro-Arg-OH
L-Thr-L-Lys-L-Pro-L-Arg
L-Thr-L-Lys-L-Pro-L-Arg-OH
Taftsin
thr-Lys-Pro-Arg
THR-LYS-PRO-ARG 2ACOH 4H2O
TKPR
Tuftsin hydrate acetate salt
L-Arginine, N2-[1-(N2-L-threonyl-L-lysyl)-L-prolyl]- (ZCI)
L-Threonyl-L-lysyl-L-prolyl-L-arginine (ACI)
100: PN: US20060127404 SEQID: 100 claimed sequence
11: PN: WO2004002417 SEQID: 100 claimed protein
1271: PN: US20090175821 SEQID: 1558 claimed protein
137: PN: US20030119021 SEQID: 137 unclaimed protein
13: PN: WO2021226849 SEQID: 19 claimed protein
14: PN: US20030226155 SEQID: 14 unclaimed protein
14: PN: WO2007076032 TABLE: 59 unclaimed sequence
1: PN: US20040132667 SEQID: 1 unclaimed protein
1: PN: US20160256516 SEQID: 17 claimed protein
229: PN: WO0024782 SEQID: 263 claimed protein
253: PN: WO0069900 SEQID: 1558 unclaimed protein
258: PN: WO0069900 SEQID: 1563 unclaimed protein
27: PN: WO2009126037 PAGE: 5 unclaimed sequence
29: PN: US6720141 SEQID: 26 unclaimed protein
2: PN: US20110104156 SEQID: 2 claimed sequence
2: PN: WO2009033726 PAGE: 99 claimed protein
30: PN: WO2006010057 SEQID: 60 unclaimed protein
32: PN: WO2009105671 SEQID: 32 unclaimed protein

MDL Number

MFCD00076891

FAQ

What are the physical and chemical properties of Tuftsin (CAS: 9063-57-4)?

Tuftsin (CAS: 9063-57-4) is a crystalline peptide with a molecular weight of approximately 1,616.66 g/mol. It is sparingly soluble in water and ethanol but insoluble in organic solvents. Tuftsin is known for its stability and minimal reactivity under normal conditions. It is used in research for its immune-stimulating properties.

How is Tuftsin (CAS: 9063-57-4) typically synthesized?

Tuftsin (CAS: 9063-57-4) is synthesized via solid-phase peptide synthesis (SPPS) using standard Fmoc chemistry. Commonly, the synthesis involves the coupling of amino acids in a stepwise manner, with the use of HATU and DIPEA as coupling reagents. The final product is purified through reverse-phase HPLC to ensure high purity.

What industries use Tuftsin (CAS: 9063-57-4)?

Tuftsin (CAS: 9063-57-4) is primarily used in the pharmaceutical industry for its immune-stimulating effects. It is also utilized in research and development for its applications in immunology, vaccine development, and cancer therapy. Additionally, it can be found in some food additives for its potential immunomodulatory benefits.

What precautions should be taken when handling Tuftsin (CAS: 9063-57-4)?

When handling Tuftsin (CAS: 9063-57-4), it is important to wear appropriate personal protective equipment (PPE) such as gloves, lab coat, and safety goggles. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately with appropriate absorbent materials, and proper disposal methods should be followed as outlined in the Safety Data Sheet (SDS).