Tivantinib | CAS No. 905854-02-6

Tivantinib

Basic Information

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CAS Number

905854-02-6

Molecular Formula

C23H19N3O2

Molecular Weight

369.42 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Boiling Point

715.95°C at 760 mmHg

Density

1.49

SMILES

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C1CC2=C3C(=CC=C2)C(=CN3C1)C4C(C(=O)NC4=O)C5=CNC6=CC=CC=C65

InChI

InChI=1S/C23H19N3O2/c27-22-19(16-11-24-18-9-2-1-7-14(16)18)20(23(28)25-22)17-12-26-10-4-6-13-5-3-8-15(17)21(13)26/h1-3,5,7-9,11-12,19-20,24H,4,6,10H2,(H,25,27,28)/t19-,20-/m0/s1

InChIKey

UCEQXRCJXIVODC-PMACEKPBSA-N

LogP

3.592600000000002

Topological Polar Surface Area

66.89 Å²

Hydrogen Bond Donor/Acceptor

2 / 5

Complexity

666

Safety Information

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Hazard Statement

H317 May cause an allergic skin reaction
Sensitization, Skin

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

(3R,4R)-3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione
Tivantinib
ARQ 197
Tivantinib (ARQ 197)
2,5-Pyrrolidinedione, 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij] quinolin-1-yl)-4-(1H-indol-3-yl)-, (3R,4R)-
2,5-Pyrrolidinedione,3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-, (3R...
3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione
ARQ 197 (ARQ-197,Tivantinib)
ARQ 197 (Tivantinib)
ARQ-197
(-)-3(R),4(R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione
(-)-3(R),4(R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione,(-)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione
(3R,4R)-3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-2,5-pyrrolid
TIVANTINIB ARQ-197
ARQ197
PJ4H73IL17
(3R,4R)-3-(5,6-Dihydro-4H-pyrrolo(3,2,1-ij)quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione
Tivantinib [USAN:INN]
Tivantinib; ARQ197
ARQ 197, Tivantinib
Tivantinib (JAN/USAN/INN)
GTPL7948
(3R,4R)-3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-2,5-pyrrolidinedione (ACI)
905854-02-6
Tivantinib [INN]
NSC-800951
CCG-268285
TIVANTINIB [JAN]
SCHEMBL44944
2,5-Pyrrolidinedione, 3-(5,6-dihydro-4H-pyrrolo(3,2,1-ij)quinolin-1-yl)-4-(1H-indol-3-yl)-, (3R,4R)-
NSC758242

MDL Number

MFCD11977597

FAQ

What is Tivantinib (CAS: 905854-02-6)?

Tivantinib (CAS: 905854-02-6) is a small molecule inhibitor of c-Met tyrosine kinase, used in the treatment of advanced solid tumors, particularly in combination with chemotherapy. It is a promising therapeutic agent in cancer research and clinical trials.

What are the main uses of Tivantinib (CAS: 905854-02-6)?

Tivantinib (CAS: 905854-02-6) is primarily used in clinical oncology as a targeted therapy to treat advanced solid tumors. It is also studied for its potential in combination therapies and as a single agent in various clinical trials for different types of cancer.

Is Tivantinib (CAS: 905854-02-6) safe?

Tivantinib (CAS: 905854-02-6) is generally considered safe when used under medical supervision. However, it can cause side effects such as gastrointestinal issues, fatigue, and rash. Appropriate monitoring and care are essential to minimize risks.

How should Tivantinib (CAS: 905854-02-6) be stored?

Tivantinib (CAS: 905854-02-6) should be stored at a temperature below 25°C (77°F) to maintain its stability. Protect from moisture and light. Store in a tightly sealed container to prevent degradation. Keep out of reach of children and away from incompatible materials.