4-(3-Chlorophenyl)-1,3-thiazol-2-amine

Basic Information

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CAS Number

90533-23-6

Molecular Formula

C9H7ClN2S

Molecular Weight

210.69 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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C1=CC(=CC(=C1)Cl)C2=CSC(=N2)N

InChI

InChI=1S/C9H7ClN2S/c10-7-3-1-2-6(4-7)8-5-13-9(11)12-8/h1-5H,(H2,11,12)

InChIKey

QSEDBGULKWHVNE-UHFFFAOYSA-N

LogP

3.0457

Topological Polar Surface Area

38.91 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

179

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

2-amino-4-(3-chloro phenyl) thiazole
4-(3-chlorophenyl)thiazol-2-amine
CS-0136618
A843576
Z48847664
4-(3-Chloro-phenyl)-thiazol-2-ylamine
QSEDBGULKWHVNE-UHFFFAOYSA-N
90533-23-6
SCHEMBL1804064
BDBM31179
Oprea1_559973
2-Amino-4-(3-chlorophenyl)thiazole
2-Thiazolamine, 4-(3-chlorophenyl)-
SY026517
EN300-39169
AB12103
thiazol-2-amine, 9
4-(3-chlorophenyl)-1,3-thiazol-2-amine
1-(3-chloro-5-fluoro-phenyl)but-3-en-1-ol;4-(3-Chlorophenyl)thiazol-2-amine
DS-14215
MFCD02664012
AKOS000137170
DTXSID30350186
2-Amino-4-(3-chlorophenyl) thiazole
4-(3-Chlorophenyl)thiazol-2-amine
2-Thiazolamine,4-(3-chlorophenyl)-
4-(3-CHLORO-PHENYL)-THIAZOL-2-YLAMINE
thiazol-2-amine,9
4-(3-chlorophenyl)thiazol-2-ylamine
4-(3-chlorophenyl)-1,3-thiazole-2-ylamine
SBB094415

MDL Number

MFCD02664012

Customs Code

2934100090

FAQ

What are the physical and chemical properties of 4-(3-Chlorophenyl)-1,3-thiazol-2-amine (CAS: 90533-23-6)?

4-(3-Chlorophenyl)-1,3-thiazol-2-amine (CAS: 90533-23-6) is a crystalline solid with a molecular weight of approximately 220.69 g/mol. It has a moderate solubility in common organic solvents like DMSO and ethanol. The compound shows basic behavior, which can affect its reactivity. It is stable under normal conditions but may react with strong acids or bases.

How is 4-(3-Chlorophenyl)-1,3-thiazol-2-amine (CAS: 90533-23-6) typically synthesized?

4-(3-Chlorophenyl)-1,3-thiazol-2-amine can be synthesized through a multi-step process involving the coupling of 3-chlorophenyl isocyanate with thiosemicarbazide. The reaction typically requires an appropriate base and is conducted in solvents like DMF. The yield is generally high, but conditions must be carefully controlled to ensure selectivity.

What industries use 4-(3-Chlorophenyl)-1,3-thiazol-2-amine (CAS: 90533-23-6)?

4-(3-Chlorophenyl)-1,3-thiazol-2-amine is used in pharmaceuticals for its biological activity and potential as a drug candidate. It also finds applications in the synthesis of other complex molecules and in the development of sensors. While its use in semiconductors is less common, it may contribute to the development of new materials in this field.

What precautions should be taken when handling 4-(3-Chlorophenyl)-1,3-thiazol-2-amine (CAS: 90533-23-6)?

When handling 4-(3-Chlorophenyl)-1,3-thiazol-2-amine (CAS: 90533-23-6), appropriate personal protective equipment (PPE) should be worn, including gloves and goggles. The compound should be stored in a cool, dry place away from direct sunlight. In case of spill, the area should be ventilated and the spill cleaned up using appropriate absorbent materials. Always consult the Safety Data Sheet (SDS) for detailed guidelines.