Bicalutamide | CAS No. 90357-06-5

Bicalutamide

Basic Information

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CAS Number

90357-06-5

Molecular Formula

C18H14F4N2O4S

Molecular Weight

430.37 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Nitriles

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

White to Yellow Solid

Melting Point

194.0 to 198.0 deg-C

Boiling Point

650.3°C at 760 mmHg

Density

1.5200

Solubility

DMSO: >5mg/mL

Vapor Pressure

7.54X10-15 mm Hg at 25 °C (est)

SMILES

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CC(CS(=O)(=O)C1=CC=C(C=C1)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O

InChI

InChI=1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)

InChIKey

LKJPYSCBVHEWIU-UHFFFAOYSA-N

LogP

4.03338

Complexity

750

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H360 May damage fertility or the unborn child
Reproductive toxicity

Hazard Class

Class 9 Class 9

Sensitiveness

对光敏感

Synonyms & References

English

Bicalutamide
Bicalutamide (Subject to patent free)
4-cyano-3-trifluoromethyl-N-(3-p-fluorophenylsulfonyl-2-hydroxy-2-methylpropionyl)aniline
N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorophenyl)sulfonyl-2-hydroxy-2-methyl-propanamid
Bicalutamidec
Bicalutumide (CDX, ICI 176334, Casodex®, Cosudex®, Calutide®, Kalumid®)
Bicaiutamide
BicalutaMide API
Cosudex
ODEX
Bicalutamide (CDX)
Casodex
N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropionamide
N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorophenyl)sulfonyl-2-hydroxy-2-methyl-propanamide
Calutide
ICI 176334
N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorophenyl)sulfonyl-2-hydroxy-2-methylpropanamide
Bicalutamide (Casodex)
LKJPYSCBVHEWIU-UHFFFAOYSA-N
(+-)-4'-Cyano-alpha,alpha,alpha-trifluoro-3-((p-fluorophenyl)sulfonyl)-2-methyl-m-lactotoluidide
C18H14F4N2O4S
ICI 176,334
CPD000466329
Propanami
N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide (ACI)
Propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-, (±)- (ZCI)
(±)-4′-Cyano-α,α,α-trifluoro-3-[(p-fluorophenyl)sulfonyl]-2-methyl-m-lactotoluidide
Casode
ZD 176334
N-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl)-2-hydroxy-2-methylpropanamide

MDL Number

MFCD00869971

Customs Code

2929909090

FAQ

What is Bicalutamide (CAS: 90357-06-5)?

Bicalutamide is a nonsteroidal anti-androgen compound used primarily in the treatment of prostate cancer. It has the chemical formula C20H24N2O and is known for its ability to block the effects of androgens like testosterone. It is a white to off-white crystalline powder with low solubility in water and is commonly formulated as a tablet for oral administration.

What are the main uses of Bicalutamide (CAS: 90357-06-5)?

Bicalutamide is mainly used in pharmaceuticals to treat hormone-sensitive prostate cancer. It is also employed in research for studying androgen receptor inhibition and in industrial settings for the synthesis of other compounds. Due to its chemical properties, it may find use in drug development and as a chemical intermediate in various applications.

Is Bicalutamide (CAS: 90357-06-5) safe?

Bicalutamide is generally considered safe when used as directed in medical treatments. However, it should be handled with care, as it may cause side effects such as gastrointestinal issues or liver toxicity. Safety standards require proper storage and use under medical supervision to ensure it is both effective and safe for patients.

How should Bicalutamide (CAS: 90357-06-5) be stored?

Bicalutamide should be stored in a cool, dry, and dark place, away from moisture and direct sunlight. It is typically kept in a sealed container at a temperature between 15°C to 25°C. Proper storage ensures its stability and maintains its potency for pharmaceutical use.