Fostamatinib | CAS No. 901119-35-5

Fostamatinib

Basic Information

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CAS Number

901119-35-5

Molecular Formula

C23H26FN6O9P

Molecular Weight

580.47 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Insecticides

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Boiling Point

814.2±75.0°C at 760 mmHg

Density

1.496

SMILES

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CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)(O)O)C

InChI

InChI=1S/C23H26FN6O9P/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29)

InChIKey

GKDRMWXFWHEQQT-UHFFFAOYSA-N

LogP

3.094500000000001

Topological Polar Surface Area

186.71999999999997 Å²

Hydrogen Bond Donor/Acceptor

4 / 15

Complexity

904

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

Fostamatinib
Fostamatinib (R788)
R788
[6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxopyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate
FOSTAMATINIB DISODIUM
R788(Fostamatinib)
R-788
R788 compound
6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one (ACI)
R 788
(6-((5-FLUORO-2-((3,4,5-TRIMETHOXYPHENYL)AMINO)PYRIMIDIN-4-YL)AMINO)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-PYRIDO(3,2-B)(1,4)OXAZIN-4-YL)METHYL DIHYDROGEN PHOSPHATE
R-788 Free acid
CHEMBL2103830
R-935788
6-((5-Fluoro-2-((3,4,5-trimethoxyphenyl)amino)-4-pyrimidinyl)amino)-2,2-dimethyl-4-((phosphonooxy)methyl)-2h-pyrido(3,2-b)-1,4-oxazi n-3(4h)-one
2RC
J-517972
[6-({5-Fluoro-2-[(3,4,5-Trimethoxyphenyl)amino]pyrimidin-4-Yl}amino)-2,2-Dimethyl-3-Oxo-2,3-Dihydro-4h-Pyrido[3,2-B][1,4]oxazin-4-Yl]methyl Dihydrogen Phosphate
EN300-20332957
(6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-3-oxo-2,3-dihydropyrido[3,2-b][1,4]oxazin-4-yl)methyl dihydrogen phosphate
BCP01871
NCGC00346622-01
NSC800102
s2625
Fostamatinib(R788)?
R935788 FREE ACID
Fostamatinib (USAN)
R788 (Fostamatinib)
GKDRMWXFWHEQQT-UHFFFAOYSA-N
PB25570
NCGC00346622-02

MDL Number

MFCD16628163

FAQ

What is Fostamatinib (CAS: 901119-35-5)?

Fostamatinib (CAS: 901119-35-5) is a spleen tyrosine kinase (SYK) inhibitor used in the treatment of chronic immune thrombocytopenia (ITP) and rheumatoid arthritis. It is an oral medication that has anti-inflammatory and immunomodulatory properties.

What are the main uses of Fostamatinib (CAS: 901119-35-5)?

Fostamatinib (CAS: 901119-35-5) is primarily used in the treatment of chronic immune thrombocytopenia (ITP) and rheumatoid arthritis. It can also be used in clinical trials and research to study its effects on other autoimmune and inflammatory diseases.

Is Fostamatinib (CAS: 901119-35-5) safe?

Fostamatinib (CAS: 901119-35-5) is generally considered safe when used as directed under medical supervision. However, it may cause side effects such as infections, headache, and diarrhea. Patients should consult their healthcare provider if they experience any adverse effects.

How should Fostamatinib (CAS: 901119-35-5) be stored?

Fostamatinib (CAS: 901119-35-5) should be stored at room temperature (15-30°C), protected from light and moisture. It should be kept in a tightly closed container to maintain its efficacy and stability. Avoid exposure to extreme temperatures or direct sunlight.