2-hydroxybenzaldehyde

Basic Information

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CAS Number

90-02-8

Molecular Formula

C7H6O2

Molecular Weight

122.12 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Aldehydes

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

1-2 °C

Boiling Point

197 °C

Density

1.146 g/mL at 25 °C

Solubility

4.9g/l

Refractive Index

n20/D 1.573(lit.)<br />n20/D 1.573

Vapor Pressure

1 mmHg ( 33 °C)

SMILES

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Oc1ccccc1C=O

InChI

InChI=1S/C7H6O2/c8-5-6-3-1-2-4-7(6)9/h1-5,9H

InChIKey

SMQUZDBALVYZAC-UHFFFAOYSA-N

LogP

1.2047

pKa

8.37(at 25℃)

Topological Polar Surface Area

37.3 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

101

Safety Information

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GHS Hazard Pictograms

H302

H311

H315

H319

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H311 Toxic in contact with skin
Acute toxicity, dermal

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class 6.1(b) Class 6.1(b)

Stability

Stable. Combustible. Incompatible with strong bases, strong reducing agents, strong acids, strong oxidizing agents.

Sensitiveness

Air & Light Sensitive

Toxicity

MLD in rats (mg/kg): 900-1000 s.c. (Binet)

Synonyms & References

English

2-Hydroxybenzaldehyde
Salicylaldehyde
2-FORMYLPHENOL
2-hydroxy-benzaldehyde
2-hydroxyl-1-benzaldehyde
2-hydroxylphenylaldehyde
FEMA 3004
o-Formylphenol
ortho-hydroxybenzaldehyde
salicyaldehyde
salicyladehyde
Salicylal
SALICYLALDEHYD
SALICYLIALDENYDE
Salicylic aldehyde
2-Formylphenol
2-Hydroxybenzaldehyde (ACI)
Salicylaldehyde (8CI)
2-Hydroxy-1-benzaldehyde
NSC 112278
NSC 49178
NSC 83559
NSC 83560
NSC 83561
NSC 83562
NSC 97202
o-Hydroxybenzaldehyde

MDL Number

MFCD00003317

FAQ

What are the physical and chemical properties of 2-hydroxybenzaldehyde (CAS: 90-02-8)?

2-hydroxybenzaldehyde (CAS: 90-02-8) is a white crystalline solid with a molecular weight of approximately 138.13 g/mol. It is slightly soluble in water and readily soluble in ethanol. It has a pKa of around 15.4, indicating its basic nature. The compound is relatively stable under normal conditions but can undergo condensation reactions under acidic conditions. It has a pleasant aroma and is used in flavoring and fragrance applications.

How is 2-hydroxybenzaldehyde (CAS: 90-02-8) typically synthesized?

2-hydroxybenzaldehyde (CAS: 90-02-8) is often synthesized from hydroxybenzoic acid via decarboxylation. This process involves heating hydroxybenzoic acid with a suitable base such as sodium hydroxide in an alcoholic solvent. Another method involves the reduction of 2-hydroxybenzaldehyde oxime using hydrogen gas and a nickel catalyst. The yield and selectivity of these methods can be influenced by reaction conditions and choice of catalysts.

What industries use 2-hydroxybenzaldehyde (CAS: 90-02-8)?

2-hydroxybenzaldehyde (CAS: 90-02-8) is primarily used in the food and fragrance industries for its aromatic properties. It is also employed in the pharmaceutical sector for the synthesis of certain drugs. Additionally, it has applications in the production of polymers, where it can act as a monomer. Its reactivity and stability make it suitable for use in sensors and semiconductors as well.

What precautions should be taken when handling 2-hydroxybenzaldehyde (CAS: 90-02-8)?

Proper personal protective equipment (PPE) should be used when handling 2-hydroxybenzaldehyde (CAS: 90-02-8), including gloves, safety goggles, and a lab coat. It should be handled in a well-ventilated area or a fume hood to avoid inhalation of vapors. Spills should be cleaned up immediately using appropriate absorbents, and the area should be flushed with water. Safety data sheets (SDS) should be consulted for detailed emergency procedures and storage guidelines.