N-(2-Hydroxyethyl)-6-oxo-3-piperidinecarboxamide(CAS: 896133-95-2)

N-(2-Hydroxyethyl)-6-oxo-3-piperidinecarboxamide is a white crystalline solid with a molecular weight of approximately 221.26 g/mol. It has a pKa of around 8.2. The compound is moderately soluble in water and ethanol. It shows good reactivity with carboxylic acid derivatives and can form esters under appropriate conditions. It is a stable compound under normal storage conditions, but may degrade upon exposure to strong acids or bases.

N-(2-Hydroxyethyl)-6-oxo-3-piperidinecarboxamide is typically synthesized via the condensation of 6-oxo-3-piperidinecarboxaldehyde with 2-hydroxyethylamine. The reaction is catalyzed by a Lewis acid like aluminum chloride and proceeds with good selectivity and yield. The final product can be purified by recrystallization from a suitable solvent like ethanol.

N-(2-Hydroxyethyl)-6-oxo-3-piperidinecarboxamide is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It also finds application in the polymer industry as a stabilizer and in the formulation of certain coatings. Additionally, it is used in the development of sensors and as a component in some semiconductor materials.

When handling N-(2-Hydroxyethyl)-6-oxo-3-piperidinecarboxamide, it is important to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and protective clothing. It should be used in a well-ventilated area or within a fume hood. Spills should be immediately cleaned up using suitable absorbents. In case of exposure, seek medical attention. The safety data sheet (SDS) should be consulted for detailed information on handling and storage.