6-Bromo-5-methylpyridin-2-amine

Basic Information

View in Editor

CAS Number

89466-17-1

Molecular Formula

C6H7BrN2

Molecular Weight

187.04 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

96-98 ºC

Boiling Point

287.3±35.0 ºC (760 Torr),

Density

1.593±0.06 g/cm3 (20 ºC 760 Torr),

Flash Point

127.6±25.9 ºC,

SMILES

View in Editor

CC1=C(N=C(C=C1)N)Br

InChI

InChI=1S/C6H7BrN2/c1-4-2-3-5(8)9-6(4)7/h2-3H,1H3,(H2,8,9)

InChIKey

DDCMBKXJOGOCPM-UHFFFAOYSA-N

LogP

1.7347199999999998

Topological Polar Surface Area

38.91 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

97.1

Synonyms & References

English

6-Bromo-5-methylpyridin-2-amine
6-Bromo-5-methyl-2-pyridinamine
6-Amino-2-bromo-3-methylpyridine
5-Methyl-6-bromopyridine-2-amine
2-Pyridinamine, 6-bromo-5-methyl-
SB13712
NE60665
AK138089
3-Picoline, 6-amino-2-bromo- (7CI)
6-Bromo-5-methyl-2-pyridinamine (ACI)
AKOS022173599
DTXSID70731172
SY099419
MFCD20704687
DS-5953
SCHEMBL8180922
DA-36414
CS-0050259
AKOS032949977
89466-17-1
2-Amino-6-bromo-5-methylpyridine
EN300-99108
F13890

MDL Number

MFCD20704687

FAQ

What are the physical and chemical properties of 6-Bromo-5-methylpyridin-2-amine (CAS: 89466-17-1)?

6-Bromo-5-methylpyridin-2-amine is a white crystalline solid with a molecular weight of approximately 214.05 g/mol. It has a solubility of about 20 mg/mL in water and is slightly soluble in ethanol. The compound exhibits good solubility in organic solvents like DMF and DMSO. It is moderately reactive towards basic conditions and shows limited reactivity under normal storage conditions.

How is 6-Bromo-5-methylpyridin-2-amine (CAS: 89466-17-1) typically synthesized?

6-Bromo-5-methylpyridin-2-amine is typically synthesized via a multistep process involving the bromination of 5-methylpyridin-2-amine followed by reaction with a brominating agent like N-bromosuccinimide (NBS). The reaction is often conducted in the presence of a suitable solvent such as DMF. The yield is generally around 70-80%, and the reaction is selective and favorable.

What industries use 6-Bromo-5-methylpyridin-2-amine (CAS: 89466-17-1)?

6-Bromo-5-methylpyridin-2-amine is used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the polymer industry for modifying properties of polymeric materials. Additionally, it is utilized in the sensor technology sector for developing chemical sensors and in the semiconductor industry for creating specialized coatings.

What precautions should be taken when handling 6-Bromo-5-methylpyridin-2-amine (CAS: 89466-17-1)?

Precautions when handling 6-Bromo-5-methylpyridin-2-amine include wearing appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbent materials, and the area should be well-ventilated. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.