6-Bromo-5-methylpyridin-2-amine(CAS: 89466-17-1)

6-Bromo-5-methylpyridin-2-amine is a white crystalline solid with a molecular weight of approximately 214.05 g/mol. It has a solubility of about 20 mg/mL in water and is slightly soluble in ethanol. The compound exhibits good solubility in organic solvents like DMF and DMSO. It is moderately reactive towards basic conditions and shows limited reactivity under normal storage conditions.

6-Bromo-5-methylpyridin-2-amine is typically synthesized via a multistep process involving the bromination of 5-methylpyridin-2-amine followed by reaction with a brominating agent like N-bromosuccinimide (NBS). The reaction is often conducted in the presence of a suitable solvent such as DMF. The yield is generally around 70-80%, and the reaction is selective and favorable.

6-Bromo-5-methylpyridin-2-amine is used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the polymer industry for modifying properties of polymeric materials. Additionally, it is utilized in the sensor technology sector for developing chemical sensors and in the semiconductor industry for creating specialized coatings.

Precautions when handling 6-Bromo-5-methylpyridin-2-amine include wearing appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbent materials, and the area should be well-ventilated. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.