Manidipine | CAS No. 89226-50-6

Manidipine

Basic Information

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CAS Number

89226-50-6

Molecular Formula

C35H38N4O6

Molecular Weight

610.7 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

125-128°C

Boiling Point

722°C at 760 mmHg

Density

1.232

Flash Point

390.4 °C

SMILES

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CC1=C(C(C(=C(N1)C)C(=O)OCCN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC

InChI

InChI=1S/C35H38N4O6/c1-24-30(34(40)44-3)32(28-15-10-16-29(23-28)39(42)43)31(25(2)36-24)35(41)45-22-21-37-17-19-38(20-18-37)33(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-16,23,32-33,36H,17-22H2,1-3H3

InChIKey

ANEBWFXPVPTEET-UHFFFAOYSA-N

LogP

5.68080

Complexity

1090

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
2-(4-(Diphenylmethyl)-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
2-(4-benzhydryl-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Manidipine
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester (9CI)
(±)-Manidipine
2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-[2-(4-benzhydryl-piperazin-1-yl)-ethyl] ester 5-methyl ester
Franidipine
Manidipine 6300
3-(2-(4-benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
SMR003500793
3,5-Pyridinedicarboxylic acid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester, (A+/-)-
Manidipine(CV-4093)
AB01274741_04
BDBM50227969
89226-50-6
SW219347-1
Iperten
US20230414632, Compound I-g
HMS2089K12
Artedil (TN)
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester
Q921133
BCP9000919
AB01274741-02
3-{2-[4-(diphenylmethyl)piperazin-1-yl]ethyl} 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
2-(4-(DIPHENYLMETHYL)-1-PIPERAZINYL)ETHYL METHYL (+/-)-1,4-DIHYDRO-2,6-DIMETHYL-4-(M-NITROPHENYL)-3,5-PYRIDINECARBOXYLATE
ANEBWFXPVPTEET-UHFFFAOYSA-N
BRD-A90695733-001-08-2
NCGC00167493-02
DB09238

MDL Number

MFCD00871291

FAQ

What regulatory guidelines apply to Manidipine (CAS: 89226-50-6)?

Manidipine (CAS: 89226-50-6) is regulated under the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), REACH in Europe, and FDA/EPA guidelines. Manufacturers and handlers must comply with specific classification, labeling, and storage requirements, as well as environmental, health, and safety regulations applicable to pharmaceutical chemicals.

Are there alternatives to Manidipine (CAS: 89226-50-6) in synthesis?

While Manidipine (CAS: 89226-50-6) is a well-established antihypertensive, alternatives such as isomers, analogs like amlodipine, and other calcium channel blockers are used in synthesis. Common alternative reagents include nitriles and alkyl halides, which can serve as effective substitutes depending on the specific synthesis route.

What is the market or research trend for Manidipine (CAS: 89226-50-6)?

The market for Manidipine (CAS: 89226-50-6) is stable, with ongoing research focused on its cardiovascular benefits and potential for treating hypertension. Recent trends include exploration of its use in combination therapies and studies on its long-term safety and efficacy. Research is also examining its role in managing other cardiovascular conditions.

How should waste containing Manidipine (CAS: 89226-50-6) be handled?

Waste containing Manidipine (CAS: 89226-50-6) should be collected in appropriate containers and disposed of through professional waste disposal services. Incineration is a common method, provided it adheres to local environmental regulations. Handlers should follow all safety precautions and ensure that waste is appropriately labeled for hazardous waste disposal to prevent environmental contamination.