Nutlin-3 | CAS No. 890090-75-2

Nutlin-3

Basic Information

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CAS Number

890090-75-2

Molecular Formula

C30H30Cl2N4O4

Molecular Weight

581.49 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Density

1.36

SMILES

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CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

InChI

InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)

InChIKey

BDUHCSBCVGXTJM-UHFFFAOYSA-N

LogP

5.885800000000006

Topological Polar Surface Area

83.47 Å²

Hydrogen Bond Donor/Acceptor

1 / 8

Complexity

919

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

4-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one
2-Piperazinone, 4-[[4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1 H -imidazol-1-yl]carbonyl]-
4-[[4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-Piperazinone
4-{[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5- dihydro-1H-imidazol-1-yl]carbonyl}-2-piperazinone
NUTLIN 3
Nutlin-3
Nutlin 3(Random Configuration)
(+/-)-Nutlin3
4-[4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one
2-Piperazinone,4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-
4-[[4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone (ACI)
4-[4,5-Bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one
MFCD07784509
SW220144-1
(??)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one
AS-10121
Q27165473
Z2159890360
4-[[4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone
MFCD14636430
SCHEMBL2458627
HMS3651G03
the p53/MDM2 Agonist
NCGC00165848-02
BDBM31197
(+)-Nutlin-3
DB-003450
BRD-A12230535-001-11-7
J-523776
(+-)-4-[4,5-dihydro-imidazole-1-carbonyl]piperazin-2-one
4-({4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one

MDL Number

MFCD07784509

FAQ

What regulatory guidelines apply to Nutlin-3 (CAS: 890090-75-2)?

Nutlin-3 (CAS: 890090-75-2) falls under the jurisdiction of several regulatory guidelines including the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), REACH regulations in the European Union, and FDA/EPA requirements for chemical safety. Manufacturers must ensure compliance with these guidelines for proper classification, labeling, and handling of the compound.

Are there alternatives to Nutlin-3 (CAS: 890090-75-2) in synthesis?

There are several alternatives to Nutlin-3 (CAS: 890090-75-2) that can be used in synthesis. Common analogs and isomers include analogs with modified substituents. Alternative reagents such as staurosporine and H10404 are often used as substitutes in various chemical reactions, depending on the specific application.

What is the market or research trend for Nutlin-3 (CAS: 890090-75-2)?

Nutlin-3 (CAS: 890090-75-2) shows strong research trends in the field of cancer treatment, particularly for its role as a p53 activator. Market demand is growing due to its potential in targeted cancer therapy. Additionally, there is increasing interest in its use in preclinical studies for developing novel anticancer drugs.

How should waste containing Nutlin-3 (CAS: 890090-75-2) be handled?

Waste containing Nutlin-3 (CAS: 890090-75-2) should be collected in a closed, labeled container and stored in a safe, secure area. Proper waste disposal should follow local regulations. For disposal, professional hazardous waste facilities should be contacted to handle the waste through incineration or other environmentally friendly methods to ensure compliance with environmental protection regulations.