4,4,5,5-Tetramethyl-2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-1,3,2-dioxaborolane | CAS No. 889865-38-7
4,4,5,5-Tetramethyl-2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-1,3,2-dioxaborolane
Basic Information
CAS Number
889865-38-7
Molecular Formula
C17H25BO4
Molecular Weight
304.2 g/mol
AD
Basic Physical Properties
Melting Point
57.0 to 61.0 deg-C
Safety Information
View Safety InformationHazard Statement
H315
Causes skin irritation
Skin corrosion/irritation
Skin corrosion/irritation
H319
Causes serious eye irritation
Serious eye damage/eye irritation
Serious eye damage/eye irritation
H335
May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation
Synonyms & References
English
- 4,4,5,5-Tetramethyl-2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-1,3,2-dioxaborolane
- 4-(tetrahydro-2H-pyran-2-yloxy)phenylboronic acid pinacol ester
- 4,4,5,5-tetramethyl-2-[4-(oxan-2-yloxy)phenyl]-1,3,2-dioxaborolane
- 4-(4,4,5,5-tetramethyl-1,3,2-dioxoborolan-2-yl)-1-(2-tetrahydropyranyloxy)benzene
- 4-(tetrahydro-2H-pyran-2-yloxy)-phenylboronic acid pinacol ester
- 4-[(Tetrahydro-2H-pyran-2-yl)oxy]phenylboronic Acid Pinacol Ester
- 2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolane-2-yl)phenoxy]tetrahydro-2H-pyran
- ZIKLUMIQYINQLY-UHFFFAOYSA-N
- KM2788
- AM62780
- BC000842
- AX8225181
- ST24042538
- 2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]oxane
- 4,4
- 4,4,5,5-tetramethyl-2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-1,3,2-dioxaborolane
- Tetrahydro-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]-2H-pyran (ACI)
- 889865-38-7
- CS-0112420
- MFCD16294419
- 4,4,5,5-Tetramethyl-2-[4-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]-1,3,2-dioxaborolane
- 4,4,5,5-TETRAMETHYL-2-[4-(OXAN-2-YLOXY)PHENYL]-1,3,2-DIOXABOROLANE
- SCHEMBL8265696
- T3468
- DTXSID30728604
- SY101990
- Tetrahydro-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]-2H-pyran
- AS-11411
- AKOS015968926
MDL Number
MFCD16294419
Customs Code
2934999090
FAQ
What are the physical and chemical properties of 4,4,5,5-Tetramethyl-2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-1,3,2-dioxaborolane (CAS: 889865-38-7)?
4,4,5,5-Tetramethyl-2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-1,3,2-dioxaborolane is a colorless crystalline solid with a molecular weight of approximately 379.4 g/mol. It has a low solubility in water but is soluble in organic solvents such as acetone and ethanol. It exhibits moderate reactivity towards nucleophiles, which is typical for dioxaborolanes, and is often used in Suzuki coupling reactions.
How is 4,4,5,5-Tetramethyl-2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-1,3,2-dioxaborolane (CAS: 889865-38-7) typically synthesized?
4,4,5,5-Tetramethyl-2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-1,3,2-dioxaborolane can be synthesized through a multistep process involving protection of a pyran ring, followed by introduction of a phenolic group. Key reactions include a Wittig reaction, a boronation step using boronpins, and a debenzylation step. The overall yield is around 70-80%, and the reaction is typically catalyzed by palladium(II) acetate.
What industries use 4,4,5,5-Tetramethyl-2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-1,3,2-dioxaborolane (CAS: 889865-38-7)?
4,4,5,5-Tetramethyl-2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-1,3,2-dioxaborolane is primarily used in the pharmaceutical and polymer industries. It is a key reagent in organic synthesis, particularly in the preparation of boron-containing compounds for medicinal applications. Its versatile reactivity also makes it useful in the synthesis of functional polymers and sensors.
What precautions should be taken when handling 4,4,5,5-Tetramethyl-2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-1,3,2-dioxaborolane (CAS: 889865-38-7)?
When handling 4,4,5,5-Tetramethyl-2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-1,3,2-dioxaborolane, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work in a well-ventilated fume hood to minimize exposure. Spills should be immediately contained and cleaned up with appropriate solvents. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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