3-Amino-1H-indazol-6-ol(CAS: 88805-72-5)

3-Amino-1H-indazol-6-ol (CAS: 88805-72-5) is a crystalline solid with a molecular weight of approximately 161.21 g/mol. It is slightly soluble in water and ethanol. The compound is known for its basic nature and reactivity in organic synthesis, particularly in nucleophilic substitution and condensation reactions.

3-Amino-1H-indazol-6-ol is commonly synthesized via the Curtius rearrangement of indole-3-carbinol, using anhydrous hydroiodic acid as a catalyst. The reaction yields a high purity product with good selectivity and a high yield of 80-90%. Other methods include direct reduction of indazole-6-one with sodium borohydride.

3-Amino-1H-indazol-6-ol (CAS: 88805-72-5) is primarily used in the pharmaceutical industry as a precursor for the synthesis of various indazolone derivatives with potential medicinal applications. It is also explored in the polymer and semiconductor industries for its electronic and optical properties.

When handling 3-Amino-1H-indazol-6-ol (CAS: 88805-72-5), appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Work should be conducted in a fume hood to minimize inhalation risks. In case of a spill, it should be neutralized with an appropriate acid or base and disposed of according to local waste regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information.