5-Amino-2-hydroxy-4'-sulfo-[1,1'-biphenyl]-3-carboxylic acid | CAS No. 887256-40-8

5-Amino-2-hydroxy-4'-sulfo-[1,1'-biphenyl]-3-carboxylic acid

Basic Information

CAS Number

887256-40-8

Molecular Formula

C13H11NO6S

Molecular Weight

309.3 g/mol

AD

Basic Physical Properties

C1=CC(=CC=C1C2=C(C(=CC(=C2)N)C(=O)O)O)S(=O)(=O)O

InChI

InChI=1S/C13H11NO6S/c14-8-5-10(12(15)11(6-8)13(16)17)7-1-3-9(4-2-7)21(18,19)20/h1-6,15H,14H2,(H,16,17)(H,18,19,20)

InChIKey

JFHCLENXDPFHHY-UHFFFAOYSA-N

LogP

1.5862999999999998

Topological Polar Surface Area

137.92000000000002 Ų

Hydrogen Bond Donor/Acceptor

5 / 7

Complexity

479

Synonyms & References

English

  • 5-Amino-3-(4-sulfonylphenyl)salicyclic Acid
  • Mesalazine EP Impurity P
  • Mesalamine impurity P
  • 5-Amino-2-hydroxy-4′-sulfo[1,1′-biphenyl]-3-carboxylic acid (ACI)
  • 5-amino-2-hydroxy-4'-sulfo-[1,1'-biphenyl]-3-carboxylic acid
  • 5-Amino-2-hydroxy-4'-sulfo[1,1'-biphenyl]-3-carboxylic Acid; 5-Amino-2-hydroxy-3-(4-sulfophenyl)benzoic Acid; 3-(4-Sulfophenyl)-5-aminosalicylic Acid; Mesalamine impurity P; 3-(4-sulfophenyl)-5-aminosalicylic Acid
  • 5-Amino-2-hydroxy-4'-sulfo-[1,1'-biphenyl]-3-carboxylicacid
  • 5-Amino-3-(4-sulfonylphenyl)salicyclic Acid Sodium Salt
  • AKOS027323309
  • (1,1'-Biphenyl)-3-carboxylic acid, 5-amino-2-hydroxy-4'-sulfo-
  • 5-AMINO-2-HYDROXY-3-(4-SULFOPHENYL)BENZOIC ACID
  • 5-Amino-2-hydroxy-4a(2)-sulfo[1,1a(2)-biphenyl]-3-carboxylic acid
  • Mesalazine impurity P [EP]
  • 5-Amino-2-hydroxy-4'-sulfo-[1,1'-biphenyl]-3-carboxylic acid
  • UNII-OVF1UF1IB2
  • 5-Amino-2-hydroxy-4'-sulfo(1,1'-biphenyl)-3-carboxylic acid
  • 887256-40-8
  • DTXSID801189679
  • MESALAZINE IMPURITY P [EP IMPURITY]
  • CS-0131954
  • OVF1UF1IB2
  • 5-Amino-2-hydroxy-4'-sulfo-[1,1'-Biphenyl]-3-carboxylic Acid Sodium Salt;
  • DA-65348
  • G87725
  • 5-Amino-2-hydroxy-4'-sulfo[1,1'-biphenyl]-3-carboxylic acid
  • HY-131265
  • 3-(4-Sulfophenyl)-5-aminosalicylic acid

MDL Number

MFCD29918713

FAQ

What are the physical and chemical properties of 5-Amino-2-hydroxy-4'-sulfo-[1,1'-biphenyl]-3-carboxylic acid (CAS: 887256-40-8)?

5-Amino-2-hydroxy-4'-sulfo-[1,1'-biphenyl]-3-carboxylic acid is a crystalline compound with a molecular weight of approximately 440.08 g/mol. It has a high solubility in water and moderate solubility in organic solvents. The compound shows good reactivity with various functional groups and exhibits acidity due to the carboxylic acid moiety.

How is 5-Amino-2-hydroxy-4'-sulfo-[1,1'-biphenyl]-3-carboxylic acid (CAS: 887256-40-8) typically synthesized?

5-Amino-2-hydroxy-4'-sulfo-[1,1'-biphenyl]-3-carboxylic acid is typically synthesized through a multistep process involving biphenol sulfation, amidation, and carboxylation reactions. Commonly, the sulfation step is catalyzed by sulfuric acid, followed by protection of the phenolic hydroxyl group and subsequent amidation with an appropriate amine. Finally, the sulfonated biphenyl is converted to the carboxylic acid derivative.

What industries use 5-Amino-2-hydroxy-4'-sulfo-[1,1'-biphenyl]-3-carboxylic acid (CAS: 887256-40-8)?

5-Amino-2-hydroxy-4'-sulfo-[1,1'-biphenyl]-3-carboxylic acid finds applications in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients, in polymer science for functionalizing polymers, in sensor technology for detecting specific analytes, and in semiconductor manufacturing as a dopant material.

What precautions should be taken when handling 5-Amino-2-hydroxy-4'-sulfo-[1,1'-biphenyl]-3-carboxylic acid (CAS: 887256-40-8)?

When handling 5-Amino-2-hydroxy-4'-sulfo-[1,1'-biphenyl]-3-carboxylic acid, it is essential to wear appropriate personal protective equipment including gloves, goggles, and a lab coat. This compound should be stored in a fume hood to minimize inhalation risks. In case of a spill, immediately clean up using appropriate absorbent materials and ensure proper disposal in accordance with local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.

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