4-Fluoropicolinic acid

Basic Information

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CAS Number

886371-78-4

Molecular Formula

C6H4FNO2

Molecular Weight

141.1 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

292.3℃ at 760 mmHg

Density

1.419

SMILES

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C1=CN=C(C=C1F)C(=O)O

InChI

InChI=1S/C6H4FNO2/c7-4-1-2-8-5(3-4)6(9)10/h1-3H,(H,9,10)

InChIKey

DOJINJNLDNIFBN-UHFFFAOYSA-N

LogP

0.9189

Topological Polar Surface Area

50.19 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

140

Safety Information

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Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

4-Fluoropicolinic acid
4-FLUORO-PYRIDINE-2-CARBOXYLIC ACID
4-Fluoropyridine-2-carboxylic acid
4-fluoropyridine-2-carboxylic acid
4-Fluoro-2-pyridinecarboxylic acid (ACI)
AB40659
4-fluoro-pyridine-2-carboxylic acid
DTXSID00592834
MFCD07374895
4-FLUORO-2-PYRIDINECARBOXYLIC ACID
CS-W022184
J-515426
886371-78-4
EN300-103100
DOJINJNLDNIFBN-UHFFFAOYSA-N
DB-001298
SCHEMBL231979
AS-45944
CL0347
AKOS005063386
SY009049
4-Fluoropicolinicacid

MDL Number

MFCD07374895

FAQ

What are the physical and chemical properties of 4-Fluoropicolinic acid (CAS: 886371-78-4)?

4-Fluoropicolinic acid is a white crystalline solid with a molecular weight of approximately 164.02 g/mol. It is slightly soluble in water and has limited solubility in common organic solvents. This compound is known for its reactivity, particularly in nucleophilic substitution reactions and as a Lewis acid catalyst in organic synthesis.

How is 4-Fluoropicolinic acid (CAS: 886371-78-4) typically synthesized?

4-Fluoropicolinic acid is usually synthesized by the fluorination of picolinic acid using reagents such as fluorine gas or hydrogen fluoride in the presence of a suitable catalyst, often a transition metal like copper. The reaction is typically conducted under anhydrous conditions and requires careful control of reaction temperature and pressure to achieve high yield and selectivity.

What industries use 4-Fluoropicolinic acid (CAS: 886371-78-4)?

4-Fluoropicolinic acid is utilized in various industries, particularly in the pharmaceutical sector for the synthesis of drugs. It also finds applications in the production of polymers and as a precursor in sensor and semiconductor manufacturing due to its chemical reactivity and Lewis acidic properties.

What precautions should be taken when handling 4-Fluoropicolinic acid (CAS: 886371-78-4)?

Proper personal protective equipment (PPE) is essential when handling 4-Fluoropicolinic acid, including gloves, safety goggles, and protective clothing. It should be stored in a cool, dry place away from sources of heat and moisture. Spills should be handled carefully using appropriate absorbents, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.