6-Fluoro-1H-indol-4-amine

Basic Information

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CAS Number

885518-25-2

Molecular Formula

C8H7FN2

Molecular Weight

150.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

361°C at 760 mmHg

Density

1.385

Flash Point

172℃

SMILES

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C1=CNC2=CC(=CC(=C21)N)F

InChI

InChI=1S/C8H7FN2/c9-5-3-7(10)6-1-2-11-8(6)4-5/h1-4,11H,10H2

InChIKey

XSFWKDMLYWEBHG-UHFFFAOYSA-N

LogP

1.8891999999999998

Topological Polar Surface Area

41.81 Å²

Hydrogen Bond Donor/Acceptor

3 / 2

Complexity

151

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

6-Fluoro-1H-indol-4-amine
1H-Indol-4-amine,6-fluoro-
1H-Indol-4-amine,6-fluoro-(9CI)
4-Amino-6-fluoroindole
1H-Indol-4-amine, 6-fluoro-
XSFWKDMLYWEBHG-UHFFFAOYSA-N
4286AC
SB15121
AK103255
ST24045360
6-fluoro-1H-indol-4-amine
6-Fluoro-1H-indol-4-amine (ACI)
CS-0043987
DTXSID80646107
SY109213
4-Amino-6-fluoro-1H-indole
AKOS006284065
DB-077884
885518-25-2
SCHEMBL11307427
DS-4057
MFCD07357294

MDL Number

MFCD07357294

FAQ

What are the physical and chemical properties of 6-Fluoro-1H-indol-4-amine (CAS: 885518-25-2)?

6-Fluoro-1H-indol-4-amine is a white or off-white crystalline solid with a molecular weight of approximately 193.15 g/mol. It has a solubility of 1.35 mg/mL in water and is slightly soluble in common organic solvents. This compound is relatively stable under normal conditions but can react with strong oxidizing agents. It is a key intermediate in the synthesis of various bioactive compounds.

How is 6-Fluoro-1H-indol-4-amine (CAS: 885518-25-2) typically synthesized?

6-Fluoro-1H-indol-4-amine is typically synthesized by the reduction of 6-fluoro-1H-indolone using sodium borohydride as the reducing agent. This process requires mild conditions and yields a high purity product. The reaction is carried out in anhydrous conditions to prevent side reactions.

What industries use 6-Fluoro-1H-indol-4-amine (CAS: 885518-25-2)?

6-Fluoro-1H-indol-4-amine is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various bioactive compounds. It is also utilized in the development of materials for sensors and semiconductors. Its unique chemical properties make it a valuable reagent in organic synthesis and material science.

What precautions should be taken when handling 6-Fluoro-1H-indol-4-amine (CAS: 885518-25-2)?

When handling 6-Fluoro-1H-indol-4-amine, it is essential to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. This compound should be stored in a fume hood to minimize inhalation risks. In case of a spill, immediately clean up using appropriate absorbent materials and follow the Material Safety Data Sheet (MSDS) for proper disposal. Always ensure good ventilation and avoid contact with water and oxidizing agents.