6-Fluoro-1H-indol-4-amine(CAS: 885518-25-2)

6-Fluoro-1H-indol-4-amine is a white or off-white crystalline solid with a molecular weight of approximately 193.15 g/mol. It has a solubility of 1.35 mg/mL in water and is slightly soluble in common organic solvents. This compound is relatively stable under normal conditions but can react with strong oxidizing agents. It is a key intermediate in the synthesis of various bioactive compounds.

6-Fluoro-1H-indol-4-amine is typically synthesized by the reduction of 6-fluoro-1H-indolone using sodium borohydride as the reducing agent. This process requires mild conditions and yields a high purity product. The reaction is carried out in anhydrous conditions to prevent side reactions.

6-Fluoro-1H-indol-4-amine is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various bioactive compounds. It is also utilized in the development of materials for sensors and semiconductors. Its unique chemical properties make it a valuable reagent in organic synthesis and material science.

When handling 6-Fluoro-1H-indol-4-amine, it is essential to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. This compound should be stored in a fume hood to minimize inhalation risks. In case of a spill, immediately clean up using appropriate absorbent materials and follow the Material Safety Data Sheet (MSDS) for proper disposal. Always ensure good ventilation and avoid contact with water and oxidizing agents.