Artesunate | CAS No. 88495-63-0

Artesunate

Basic Information

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CAS Number

88495-63-0

Molecular Formula

C19H28O8

Molecular Weight

384.43 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

132.0 to 137.0 deg-C

Boiling Point

502.1℃ at 760 mmHg

Density

1.2076 (rough estimate)

Flash Point

173.5 °C

Solubility

acetone: soluble33.4mg/mL

Refractive Index

1.4430 (estimate)

Vapor Pressure

3.2X10-9 mm Hg at 25 °C (est)

Specific Rotation

+4.5 to +6.5° (c=1, CH2Cl2)

SMILES

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CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)OC(=O)CCC(=O)O)C

InChI

InChI=1S/C19H28O8/c1-10-4-5-13-11(2)16(23-15(22)7-6-14(20)21)24-17-19(13)12(10)8-9-18(3,25-17)26-27-19/h10-13,16-17H,4-9H2,1-3H3,(H,20,21)/t10-,11-,12+,13+,16-,17-,18-,19-/m1/s1

InChIKey

FIHJKUPKCHIPAT-AHIGJZGOSA-N

LogP

2.6024000000000003

Topological Polar Surface Area

100.52000000000002 Å²

Hydrogen Bond Donor/Acceptor

1 / 8

Complexity

623

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Storage Conditions

2-8℃

Sensitiveness

thermally sensitive

Synonyms & References

English

Artesunate
ArtesunateC19H28O8
Artemisinin monosuccinate
Artesunic Acid
Butanedioic Acid Mono(3R,5aS,6R,8aS,9R,10R,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl] Ester
Arteannuinum
Arteannuinum succinate
(3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-ol hydrogen succinate
AsuMax
Cosunate
PlasMotriM
PlasMotrin
Qinghaozhi
Saphnate
vARTESUNATE
AK128401
4-Oxo-4-[[(1R,4R,8R,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexad
3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin, butanedioic acid deriv. (ZCI)
Butanedioic acid, mono(decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl) ester, [3R-(3α,5aβ,6β,8aβ,9α,10β,12β,12aR*)]- (ZCI)
Butanedioic acid, mono[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl] ester (9CI)
Arinate
Armax 200
Arsuamoon
Arsumax
Artecan
Artesunata
Artesunic acid
Asumax
Dihydroqinghasu hemsuccinate
Gsunate Forte
HC 101B

MDL Number

MFCD00866204

FAQ

What is Artesunate (CAS: 88495-63-0)?

Artesunate is an antimalarial medication derived from artemisinin, a compound found in the herb *Artemisia annua*. Its chemical formula is C15H24O5, and it is known for its high efficacy against Plasmodium falciparum, the parasite responsible for severe malaria. Artesunate is a sesquiterpene lactone and is commonly used in combination therapies to combat malaria.

What are the main uses of Artesunate (CAS: 88495-63-0)?

Artesunate is primarily used for the treatment of malaria, especially in regions where drug resistance is a concern. It is also utilized in research for its antiparasitic properties and as a key component in combination drug formulations. Additionally, it has been explored for potential applications in other parasitic infections and as a therapeutic agent in certain medical conditions.

Is Artesunate (CAS: 88495-63-0) safe?

Artesunate is generally considered safe when used as directed, but it may cause side effects such as gastrointestinal discomfort or allergic reactions in some individuals. Proper handling and adherence to safety guidelines are essential to minimize risks. It is classified as a medication with specific safety standards, and its use should be monitored by healthcare professionals.

How should Artesunate (CAS: 88495-63-0) be stored?

Artesunate should be stored in a cool, dry place away from direct sunlight. It is typically kept in airtight containers to prevent moisture exposure. The recommended storage temperature is between 15°C to 30°C, and it should be protected from humidity and light to maintain its stability and potency over time.