2-Phenyl-1-(1-piperazinyl)ethanone

Basic Information

View in Editor

CAS Number

88372-33-2

Molecular Formula

C12H16N2O

Molecular Weight

204.27 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Boiling Point

385 ºC

Density

1.101

Flash Point

186 ºC

SMILES

View in Editor

C1CN(CCN1)C(=O)CC2=CC=CC=C2

InChI

InChI=1S/C12H16N2O/c15-12(14-8-6-13-7-9-14)10-11-4-2-1-3-5-11/h1-5,13H,6-10H2

InChIKey

ZIZWHGCVLFSQBP-UHFFFAOYSA-N

LogP

0.6609

Topological Polar Surface Area

32.34 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

206

Synonyms & References

English

Cambridge id 5868216
SCHEMBL92506
HMS560O02
DTXSID60386837
2-PHENYL-1-PIPERAZINO-1-ETHANONE
CHEMBL1739935
AKOS000156445
EN300-40444
2-phenyl-1-piperazin-1-ylethanone
N-(benzylcarbonyl)piperazine
2-Phenyl-1-(piperazin-1-yl)ethan-1-one
phenylacetyl-piperazine
Oprea1_846951
2-phenyl-1-(piperazin-1-yl)ethanone
MFCD01566912
CL-218919
J-505066
Z285226212
1-(phenylacetyl)piperazine
Oprea1_812257
Piperazine, 1-(2-phenylacetyl)-
Maybridge1_006822
AB00099792-01
1-(phenylacetyl)piperazine, AldrichCPR
88372-33-2
2-Phenyl-1-(piperazin-1-yl)ethanone
1-(PHENYLACETYL)PIPERAZINE

MDL Number

MFCD01566912

FAQ

What are the physical and chemical properties of 2-Phenyl-1-(1-piperazinyl)ethanone (CAS: 88372-33-2)?

2-Phenyl-1-(1-piperazinyl)ethanone has a crystalline form with a molecular weight of approximately 252.31 g/mol. It is slightly soluble in water but more soluble in organic solvents. The compound is reactive towards nucleophiles and can undergo substitution reactions. It has a melting point of around 105-107°C.

How is 2-Phenyl-1-(1-piperazinyl)ethanone (CAS: 88372-33-2) typically synthesized?

2-Phenyl-1-(1-piperazinyl)ethanone is commonly synthesized via the condensation of 2-phenylethylenecarbodiimide with 1-piperazinecarboxylic acid. This reaction typically involves the use of a catalyst such as 4-dimethylaminopyridine to enhance the yield. The product is obtained with good selectivity and a yield of around 70-80%.

What industries use 2-Phenyl-1-(1-piperazinyl)ethanone (CAS: 88372-33-2)?

2-Phenyl-1-(1-piperazinyl)ethanone is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It also has applications in the polymer industry for the development of specific polymers, and in the sensor and semiconductor industries for specialized materials.

What precautions should be taken when handling 2-Phenyl-1-(1-piperazinyl)ethanone (CAS: 88372-33-2)?

When handling 2-Phenyl-1-(1-piperazinyl)ethanone, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work in a well-ventilated area or a fume hood to avoid inhalation. Spills should be cleaned up using appropriate absorbents, and the area should be flushed with water to remove any residue. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.