Amlodipine EP Impurity A (Amlodipine USP Related Compound D)

Basic Information

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CAS Number

88150-62-3

Molecular Formula

C28H27ClN2O7

Molecular Weight

538.98 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

153-158°C

Boiling Point

654.061°C at 760 mmHg

Density

1.321

Flash Point

349.364°C

Refractive Index

1.589

SMILES

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CCOC(=O)C1=C(COCCN2C(=O)c3ccccc3C2=O)NC(=C(C1c4ccccc4Cl)C(=O)OC)C

InChI

InChI=1S/C28H27ClN2O7/c1-4-38-28(35)24-21(15-37-14-13-31-25(32)17-9-5-6-10-18(17)26(31)33)30-16(2)22(27(34)36-3)23(24)19-11-7-8-12-20(19)29/h5-12,23,30H,4,13-15H2,1-3H3

InChIKey

AHHPZGUFLGCZCF-UHFFFAOYSA-N

LogP

3.6038000000000023

Topological Polar Surface Area

111.24 Å²

Hydrogen Bond Donor/Acceptor

1 / 9

Complexity

999

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Phthaloyl Amlodipine
3-Ethyl-5-methyl-4-(2-chlorophenyl)-2-(2-phthalimidoethoxyl)methyl-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
4-(2-Chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-2-(phthalimidoethoxy)methyl-1,4-dihydropyridine
Phthalimidoamlodipine
3-ethyl 5-methyl 4-(2-chlorophenyl)-1,4-dihydro-2-[2-(1,3-dihydro-1,3-dioxo-(2H)isoindol-2-yl)-ethoxymethyl]-6-methyl-3,5-pyridinedicarboxylate
1-Amino-6-fluoro-1,4-dihydro-7-(4-((5-methyl-2-oxo-1,3-dioxol-4-yl)methyl)piperazin-1-yl)-4-oxo-[1,3]thiazeto[3,2-A]quinoline-3-carboxylic acid
3,5-Pyridinedicarboxylicacid,4-(2-chlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]Methyl]-1,4-dihydro-6-Methyl-,3-ethyl 5-Methyl ester
4-(2-Chlorophenyl)-3-Ethoxy carbonyl-5-Methoxy carbonil-6-Methyl-2-(phthaliMidoethoxy)Methyl-1,4-dihydropyridine
4-(2-Chlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]Methyl]-1,4-dihydro-6-Methyl-3,5-pyridinedicarboxylic Acid 3-Ethyl 5-Methyl Ester
(1R,3S)-3-AMINOCYCLOHEXANOL
3-Ethyl 5-methyl 4-(2-chlorophenyl)-2-((2-(1,3-dioxoisoindolin-2-yl)ethoxy)methyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
3-O-ethyl 5-O-methyl 4-(2-chlorophenyl)-2-[2-(1,3-dioxoisoindol-2-yl)ethoxymethyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
3-Ethyl 5-methyl (4RS)-4-(2-chlorophenyl)-2-[[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
3-Ethyl 5-methyl 4-(2-chlorophenyl)-2-{[2-(1,3-dioxoisoindolin-2-yl)ethoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
3-Ethyl-5-methyl-4-(2-chlorophenyl)-2-(2-phthalimidoethoxy)methyl-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Amlodipine impurityA
Phthaloylamlodipine
Amlodipine EP Impurity A
C28H27ClN2O7
3-Ethyl 5-methyl 4-(2-chlorophenyl)-1,4-dihydro-2-(2-(1,3-dihydro-1,3-dioxo-(2H)isoindol-2-yl)-ethoxymeth
3-Ethyl 5-methyl 4-(2-chlorophenyl)-2-[[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
4-(2-Chloroethyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-2-((2-phthalimidoethoxy)methyl)-1,4-dihydropyridine
4-(2-Chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-2-[(2-phthalimidoethoxy)methyl]-1,4-dihydropyridine
3-ethyl 5-methyl 4-(2-chlorophenyl)-2-((2-(1,3-dioxoisoindolin-2-yl)ethoxy)methyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

MDL Number

MFCD07782096

FAQ

What is Amlodipine EP Impurity A (CAS: 88150-62-3)?

Amlodipine EP Impurity A, also known as Amlodipine USP Related Compound D, is a minor degradation product of amlodipine. It is a white to off-white crystalline powder with a molecular formula of C22H26N2O4.

What are the main uses of Amlodipine EP Impurity A (CAS: 88150-62-3)?

Amlodipine EP Impurity A serves as a quality control parameter in the manufacturing of amlodipine. It is used to monitor impurities in amlodipine formulations and ensure product purity and efficacy.

Is Amlodipine EP Impurity A (CAS: 88150-62-3) safe?

Amlodipine EP Impurity A is considered safe under standard handling procedures. However, it is recommended to avoid prolonged skin contact and inhalation of dust. Protective gloves and goggles should be worn during handling. Storage should be in a cool, dry place away from direct sunlight.

How should Amlodipine EP Impurity A (CAS: 88150-62-3) be stored?

Amlodipine EP Impurity A should be stored in a tightly sealed container at room temperature (15-30°C). It should be kept away from direct sunlight and protected from moisture. Avoid storing in high humidity or extreme temperatures to ensure stability.