Amlodipine Maleate

Basic Information

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CAS Number

88150-47-4

Molecular Formula

C24H29ClN2O9

Molecular Weight

524.95 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

175-179°C

Boiling Point

527.2 °C at 760 mmHg

Flash Point

272.6 °C

SMILES

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CCOC(=O)C1=C(NC(=C(C1c2ccccc2Cl)C(=O)OC)C)COCCN.C(=C\C(=O)O)\C(=O)O

InChI

InChI=1S/C20H25ClN2O5.C4H4O4/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;5-3(6)1-2-4(7)8/h5-8,17,23H,4,9-11,22H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChIKey

TZNOWAJJWCGILX-BTJKTKAUSA-N

LogP

1.9780999999999997

Topological Polar Surface Area

174.47999999999996 Å²

Hydrogen Bond Donor/Acceptor

5 / 11

Complexity

766

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Amlodipine maleate
3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate maleate
Amlodipine (maleate)
(3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chloro
2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester
2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester (z)-2-butenedioate
3-ethyl-5-methyl-(4-RS)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate maleate
Amvaz
Amlodipine maleate [USAN]
Amlodipine (+-)-form maleate
C20H25ClN2O5.C4H4O4
Amlodipine maleate (USAN)
3-Ethyl 5-methyl (+-)-2-((2-aminoethoxy)methyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate, maleate (1:1)
AmlodipineMaleate
3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (+-)-, (Z)-2-butenedioate (1:1)
(Z)-but-2-enedioic acid;3-O
3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (Z)-2-butenedioate (1:1) (ZCI)
UK 48340-11
3-ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
maleate (1:1)

MDL Number

MFCD02259457

FAQ

What regulatory guidelines apply to Amlodipine Maleate (CAS: 88150-47-4)?

Amlodipine Maleate (CAS: 88150-47-4) is regulated under various guidelines, including REACH in the European Union, which requires registration and safety data sheets. In the U.S., it is regulated by the FDA and EPA. GHS classification categorizes it as a pharmaceutical substance with specific handling and labeling requirements. Compliance with these regulations is essential for manufacturers, distributors, and users to ensure safety and legal compliance.

Are there alternatives to Amlodipine Maleate in synthesis?

While Amlodipine Maleate is a widely used calcium channel blocker, there are alternative synthetic routes and compounds, such as isometricaol or other dihydropyridine derivatives, which can serve similar therapeutic purposes. These alternatives may offer different advantages in terms of synthesis, stability, or pharmacological properties, making them valuable in research and development contexts.

What is the market or research trend for Amlodipine Maleate (CAS: 88150-47-4)?

The market for Amlodipine Maleate (CAS: 88150-47-4) is stable, with a focus on maintaining consistent supply due to its widespread use in treating hypertension and angina. Research trends are shifting towards more personalized medicine and the development of extended-release formulations to improve patient compliance. Additionally, there is an ongoing search for more effective and safer alternatives to manage cardiovascular diseases.

How should waste containing Amlodipine Maleate (CAS: 88150-47-4) be handled?

Waste containing Amlodipine Maleate (CAS: 88150-47-4) should be collected in appropriate containers lined with a suitable absorbent material to prevent leaks. Incineration is a common method for disposal, but professional waste disposal services should be utilized for larger quantities or bulk waste. Environmental protection measures include ensuring that waste does not enter waterways or soil, and all disposal activities should comply with local and national regulations to minimize environmental impact.