Amlodipine | CAS No. 88150-42-9

Amlodipine

Basic Information

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CAS Number

88150-42-9

Molecular Formula

C20H25ClN2O5

Molecular Weight

408.88 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Yellow powder

Melting Point

178-179 ºC

Water Solubility

75.3 mg/L

SMILES

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CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN

InChI

InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3

InChIKey

HTIQEAQVCYTUBX-UHFFFAOYSA-N

LogP

2.2663

Topological Polar Surface Area

99.88000000000001 Å²

Hydrogen Bond Donor/Acceptor

3 / 7

Complexity

647

Safety Information

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GHS Hazard Pictograms

H301

H318

H373

H400

H410

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

H318 Causes serious eye damage
Serious eye damage/eye irritation

H373 Causes damage to organs through prolonged or repeated exposure
Specific target organ toxicity, repeated exposure

H400 Very toxic to aquatic life
Hazardous to the aquatic environment, acute hazard

H410 Very toxic to aquatic life with long lasting effects
Hazardous to the aquatic environment, long-term hazard

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

Amlodipine
Methyl ethyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester
Amlodipine besylate
2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester
2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine
3-ethyl 5-methyl ()-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridine dicarboxylate
3-ethyl-5-methyl-(4RS)-2-[(2-aminoethoxy)-methyl]-4-(2-chlorophenyl)
Amlodipino
Amlodipinum
Norvasc
Amlodis
Coroval
Amlocard
Lipinox
AMLODIPINE BASE
Caduet
Istin
Amlodipine Free Base
Amlodipinum [Latin]
Amlodipino [Spanish]
Amlodipine [INN:BAN]
Norvasc (TN)
3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Amlor
HTIQEAQVCYTUBX-UHFFFAOYSA-N
3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
3-ethyl 5-met
(R,S)-Amlodipine
(±)-Amlodipine
2-(2-Amino-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester

MDL Number

MFCD00864687

Customs Code

2942000000

FAQ

What is Amlodipine (CAS: 88150-42-9)?

Amlodipine is a calcium channel blocker with the chemical formula C17H22N2O4. It is a white to off-white crystalline solid, commonly used in pharmaceuticals for its ability to relax blood vessels and improve blood flow. Amlodipine is known for its high selectivity for vascular smooth muscle and is widely prescribed for hypertension and coronary artery disease.

What are the main uses of Amlodipine (CAS: 88150-42-9)?

Amlodipine is primarily used in the treatment of hypertension (high blood pressure) and angina (chest pain) due to its vasodilatory effects. It is also prescribed for managing coronary artery disease and peripheral vascular disorders. As a calcium channel blocker, Amlodipine helps to reduce the workload on the heart and improve cardiac efficiency, making it a key medication in cardiovascular therapy.

Is Amlodipine (CAS: 88150-42-9) safe?

Amlodipine is generally considered safe when used as directed. It has a favorable safety profile with minimal side effects in most patients. However, like all medications, it should be handled with care and used under medical supervision. Proper storage and adherence to safety guidelines are essential to maintain its effectiveness and prevent adverse reactions.

How should Amlodipine (CAS: 88150-42-9) be stored?

Amlodipine should be stored in a cool, dry place away from direct light. It is typically kept at a temperature between 15°C to 30°C (59°F to 86°F) and should be protected from moisture. To ensure stability and potency, it should be stored in a tightly sealed container. Always follow the manufacturer's instructions for storage to maintain the drug's quality and safety.