3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine | CAS No. 877400-66-3

3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine

Basic Information

CAS Number

877400-66-3

Molecular Formula

C21H22Cl2FN5O

Molecular Weight

450.35 g/mol

AD

Basic Physical Properties

CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N

InChI

InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)

InChIKey

KTEIFNKAUNYNJU-UHFFFAOYSA-N

LogP

5.037700000000004

Topological Polar Surface Area

77.99000000000001 Ų

Hydrogen Bond Donor/Acceptor

3 / 6

Complexity

558

Safety Information

View Safety Information

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

  • racemic crizotinib
  • PB11015
  • Kinome_3143
  • 3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine
  • CHEMBL1825138
  • DTXSID10469200
  • HMS3653B11
  • Kinome_3144
  • HMS3749G05
  • HMS3654A15
  • HMS3265E12
  • PF 2341066;(R)-3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine
  • HMS3265F12
  • 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine
  • 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine
  • rac-crizotinib
  • rac-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine
  • FT-0665224
  • 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine
  • SCHEMBL94020
  • 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine (11a)
  • BCP01745
  • 2-PYRIDINAMINE, 3-[1-(2,6-DICHLORO-3-FLUOROPHENYL)ETHOXY]-5-[1-(4-PIPERIDINYL)-1H-PYRAZOL-4-YL]-
  • BDBM179803
  • 3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine
  • 3-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine;PF2341066
  • 3-(1-(2,6-dichloro-3-fluoro-phenyl)ethoxy)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-amine
  • HMS3265F11
  • (RS)-crizotinib
  • AB01566339_02
  • CERAPP_50119

MDL Number

MFCD14708244

Customs Code

2933990090

FAQ

What is 3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine (CAS: 877400-66-3)?

3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine is a complex organic compound with a distinct structure that includes a pyridinamine and a 1H-pyrazole ring. It is typically used in pharmaceuticals, particularly in the development of anti-inflammatory and analgesic drugs.

What are the main uses of 3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine (CAS: 877400-66-3)?

This compound is primarily used in the pharmaceutical industry for developing medications that target inflammation and pain. It is also utilized in research to evaluate its potential therapeutic applications.

Is 3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine (CAS: 877400-66-3) safe?

When handled properly, 3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine is generally safe. However, it should be used with caution due to its chemical structure, which includes potentially reactive functional groups. Proper protective equipment and procedures should be followed to minimize exposure and ensure safety.

How should 3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine (CAS: 877400-66-3) be stored?

This compound should be stored in a cool, dry place away from direct sunlight and heat sources. It should be kept in a tightly sealed container to prevent degradation. Proper ventilation is recommended to avoid inhalation of any volatile components. Additionally, it should be stored out of reach of children and pets.

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