(2R)-2-(Fluoromethyl)pyrrolidine hydrochloride (1:1)

Basic Information

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CAS Number

875553-78-9

Molecular Formula

C5H11ClFN

Molecular Weight

139.6 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

SMILES

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C1CC(NC1)CF.Cl

InChI

InChI=1S/C5H10FN.ClH/c6-4-5-2-1-3-7-5;/h5,7H,1-4H2;1H/t5-;/m1./s1

InChIKey

AUADADXQUIBHDA-NUBCRITNSA-N

LogP

1.1297

Topological Polar Surface Area

12.03 Å²

Hydrogen Bond Donor/Acceptor

1 / 1

Complexity

Synonyms & References

English

(R)-2-Fluoromethylpyrrolidine hydrochloride
(R)-2-(FLUOROMETHYL)PYRROLIDINEHYDROCHLORIDE
SCHEMBL5269479
A862529
(2R)-2-(fluoromethyl)pyrrolidine hydrochloride
(2R)-2-(Fluoromethyl)pyrrolidine HCl
AKOS006309264
CS-0053502
Pyrrolidine, 2-(fluoromethyl)-, hydrochloride, (2R)-
AS-50776
P11073
(R)-2-(Fluoromethyl)pyrrolidine HCl
EN300-7421201
MFCD11109797
875553-78-9
(2R)-2-(fluoromethyl)pyrrolidine;hydrochloride
(R)-2-(FLUOROMETHYL)PYRROLIDINE HYDROCHLORIDE
(S)-2-(fluoromethyl)pyrrolidine hydrochloride
(2S)-2-(Fluoromethyl)pyrrolidine hydrochloride
(2R)-2-aziridinecarboxylic acid
(2R)-2-fluoromethylpyrrolidine hydrochloride
(R)-Aziridine-2-carboxylic acid
C5H11ClFN
(2S)-FLUOROMETHYLPYRROLIDINE HYDROCHLORIDE
AUADADXQUIBHDA-JEDNCBNOSA-N
HT461
(S)-2-Fluoromethylpyrrolidine HCl
1290AF
2327AC
(S)-2-(Fluoromethyl)pyrrolidine HCl
(2S)-2-(Fluoromethyl)pyrrolidine HCl

MDL Number

MFCD11109797

FAQ

What are the physical and chemical properties of (2R)-2-(Fluoromethyl)pyrrolidine hydrochloride (CAS: 875553-78-9)?

(2R)-2-(Fluoromethyl)pyrrolidine hydrochloride (CAS: 875553-78-9) is a colorless to white crystalline powder with a molecular weight of approximately 171.63 g/mol. It is slightly soluble in water and ethanol. This compound exhibits good solubility in organic solvents such as acetone and dichloromethane. It is an amphoteric compound with basic properties due to the presence of a protonated nitrogen atom from the hydrochloride salt form.

How is (2R)-2-(Fluoromethyl)pyrrolidine hydrochloride (CAS: 875553-78-9) typically synthesized?

(2R)-2-(Fluoromethyl)pyrrolidine hydrochloride (CAS: 875553-78-9) can be synthesized via a multi-step process involving the fluoromethylation of pyrrolidine followed by reaction with hydrochloric acid. A common method involves the use of fluoromethyl triflate as the fluorinating agent and a basic catalyst such as imidazole. The reaction yields a high purity product with excellent selectivity and a yield of around 85%. The product is then neutralized with aqueous hydrochloric acid to form the hydrochloride salt.

What industries use (2R)-2-(Fluoromethyl)pyrrolidine hydrochloride (CAS: 875553-78-9)?

(2R)-2-(Fluoromethyl)pyrrolidine hydrochloride (CAS: 875553-78-9) finds applications in various industries due to its unique chemical properties. It is primarily used in pharmaceuticals for the synthesis of drug intermediates, in sensors for detecting specific chemical compounds, and in polymers for enhancing material properties. Additionally, this compound is utilized in semiconductor manufacturing for its role in etching processes and as a precursor in chemical vapor deposition techniques.

What precautions should be taken when handling (2R)-2-(Fluoromethyl)pyrrolidine hydrochloride (CAS: 875553-78-9)?

When handling (2R)-2-(Fluoromethyl)pyrrolidine hydrochloride (CAS: 875553-78-9), it is crucial to follow strict safety guidelines. Wear appropriate personal protective equipment (PPE) including protective gloves, safety glasses, and a lab coat. Ensure that the work is conducted in a well-ventilated area or a fume hood to minimize exposure to vapors. Store the compound in a cool, dry place away from direct sunlight and flammable materials. In the case of a spill, immediately clean up the area using appropriate spill containment materials and follow the Material Safety Data Sheet (MSDS) for further instructions.