How is (2R)-2-(Fluoromethyl)pyrrolidine hydrochloride (CAS: 875553-78-9) typically synthesized?

(2R)-2-(Fluoromethyl)pyrrolidine hydrochloride (CAS: 875553-78-9) can be synthesized via a multi-step process involving the fluoromethylation of pyrrolidine followed by reaction with hydrochloric acid. A common method involves the use of fluoromethyl triflate as the fluorinating agent and a basic catalyst such as imidazole. The reaction yields a high purity product with excellent selectivity and a yield of around 85%. The product is then neutralized with aqueous hydrochloric acid to form the hydrochloride salt.