Cefalexin (Cephalexin) EP Impurity A (Ampicillin EP Impurity L)

Basic Information

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CAS Number

875-74-1

Molecular Formula

C8H9NO2

Molecular Weight

151.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

302 °C (dec.)

Boiling Point

288.7°C at 760 mmHg

Density

1.2 g/cm3 (20℃)

Water Solubility

0.3g/100mL

Refractive Index

-158 ° (C=1, 1mol/L HCl)

Specific Rotation

-156 º (c=1,1N HCl)

SMILES

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N[C@@H](C(=O)O)c1ccccc1

InChI

InChI=1S/C8H9NO2/c9-7(8(10)11)6-4-2-1-3-5-6/h1-5,7H,9H2,(H,10,11)/t7-/m1/s1

InChIKey

ZGUNAGUHMKGQNY-SSDOTTSWSA-N

LogP

0.7709999999999999

Topological Polar Surface Area

63.32000000000001 Å²

Hydrogen Bond Donor/Acceptor

3 / 3

Complexity

141

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

(R)-2-Amino-2-phenylacetic acid
H-D-PHG-OH
D-(-)-2-PHENYLGLYCINE
D-2-PHENYLGLYCINE
D-(-)-A-AMINOPHENYLACETIC ACID
D(-)-ALPHA-AMINOPHENYLACETIC ACID
D-ALPHA-AMINOPHENYLACETIC ACID
(-)-D-ALPHA-PHENYLGLYCINE
D-ALPHA-PHENYLGLYCINE
D-AMINOPHENYLACETIC ACID
D-(-)-A-PHENYLAMINOACETIC ACID
D-(-)-A-PHENYLGLYCINE
D-(-)-PHENYLGLYCINE
D-PHENYLGLYCINE
H-D-(PHENYL)GLY-OH
PHENYLGLYCINE-D
(R)-(-)-2-PHENYLGLYCINE
(R)-(-)-ALPHA-AMINOPHENYLACETIC ACID
(R)-ALPHA-AMINOPHENYLACETIC ACID
(R)-(-)-ALPHA-PHENYLAMINOACETIC ACID
D-(-)-α-Phenylglycine
D-(-)-2-Phenylglycin
D(-)-alpha-Phenylglycine
D-(-)-alpha-Phenylglycine
D-(-)-α-Aminophenylacetic acid
(R)-(-)-α-Aminophenylacetic Acid
(2R)-amino(phenyl)acetic acid
(R)-Phenylglycine
(2R)-2-amino-2-phenylacetic acid
GF5LYS471N
Benzeneacetic acid, .alpha.-amino-, (R)-

MDL Number

MFCD00008061

Customs Code

29224995

FAQ

What is Cefalexin (Cephalexin) EP Impurity A (CAS: 875-74-1)?

Cefalexin EP Impurity A, also known as Ampicillin EP Impurity L, is a specific chemical impurity associated with cefalexin and ampicillin during pharmaceutical manufacturing. It has the CAS number 875-74-1 and is characterized by its structural similarity to cephalosporin and penicillin derivatives. This impurity is monitored to ensure drug purity and compliance with regulatory standards.

What are the main uses of Cefalexin (Cephalexin) EP Impurity A (CAS: 875-74-1)?

Cefalexin EP Impurity A is primarily used in pharmaceutical quality control to detect and quantify impurities in cefalexin and ampicillin preparations. It is also relevant in research for analyzing drug synthesis processes and ensuring adherence to European Pharmacopoeia (EP) specifications for antibiotic purity.

Is Cefalexin (Cephalexin) EP Impurity A (CAS: 875-74-1) safe?

Cefalexin EP Impurity A is considered a potential contaminant and should be handled with care during pharmaceutical production. While it is not an active ingredient, safety protocols include proper protective equipment and adherence to EP guidelines to minimize risks. Its presence in finished drugs is strictly regulated to ensure safety and efficacy.

How should Cefalexin (Cephalexin) EP Impurity A (CAS: 875-74-1) be stored?

Cefalexin EP Impurity A should be stored in a cool, dry, and dark environment to maintain stability. It is typically kept in airtight containers at temperatures below 25°C, away from moisture and light. Proper storage ensures compliance with pharmaceutical standards and prevents degradation during handling or analysis.