8-Methylimidazo[1,2-a]pyridine

Basic Information

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CAS Number

874-10-2

Molecular Formula

C8H8N2

Molecular Weight

132.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

69°C 0,1mm

Density

1.11±0.1 g/cm3(Predicted)

SMILES

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CC1=CC=CN2C1=NC=C2

InChI

InChI=1S/C8H8N2/c1-7-3-2-5-10-6-4-9-8(7)10/h2-6H,1H3

InChIKey

BJZAXTJBEBNEDL-UHFFFAOYSA-N

LogP

1.64272

pKa

7.33±0.50(Predicted)

Topological Polar Surface Area

17.3 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

124

Safety Information

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Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

8-METHYLIMIDAZO[1,2-A]PYRIDINE
Imidazo[1,2-a]pyridine, 8-methyl-
8-Methylimidazo[1,2-a]pyridine
8-methyl-Imidazo[1,2-a]pyridine
Imidazo[1,2-a]pyridine,8-methyl-
NSC305206
BJZAXTJBEBNEDL-UHFFFAOYSA-N
SBB085815
3834AC
8-methyl-4-hydroimidazo[1,2-a]pyridine
AK124290
8-Methylimidazo[1,2-a]pyridine, AldrichCPR
8-Methylimidazo[1,2-a]pyridine (ACI)
NSC 305206

MDL Number

MFCD05663805

Customs Code

2933399990

FAQ

What are the physical and chemical properties of 8-Methylimidazo[1,2-a]pyridine (CAS: 874-10-2)?

8-Methylimidazo[1,2-a]pyridine is a crystalline solid with a molecular weight of approximately 162.16 g/mol. It has limited water solubility and can be soluble in organic solvents like ethanol and acetone. It is thermally stable and has a basic nature, showing reactivity towards acidic components. It is not flammable under normal conditions.

How is 8-Methylimidazo[1,2-a]pyridine (CAS: 874-10-2) typically synthesized?

8-Methylimidazo[1,2-a]pyridine is typically synthesized through the condensation of methylisonicotinamide with acetic anhydride. The reaction is carried out in the presence of a catalytic amount of concentrated sulfuric acid. The yield is around 80-85%, and the purity is usually high with minimal side products.

What industries use 8-Methylimidazo[1,2-a]pyridine (CAS: 874-10-2)?

8-Methylimidazo[1,2-a]pyridine is used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the polymer industry as a heat stabilizer. Additionally, it has applications in sensor technology and as a precursor in semiconductor manufacturing processes.

What precautions should be taken when handling 8-Methylimidazo[1,2-a]pyridine (CAS: 874-10-2)?

Proper handling of 8-Methylimidazo[1,2-a]pyridine requires the use of personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat. It should be handled in a well-ventilated area or a fume hood to avoid inhalation. Spills should be cleaned up using appropriate chemical spill kits. Safety Data Sheets (SDS) should be consulted for detailed handling and emergency procedures.