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N-(3-{3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide | CAS No. 871700-17-3

N-(3-{3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide

Basic Information

Chemical_Structure_Of
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CAS Number

871700-17-3

Molecular Formula

C26H23FIN5O4

Molecular Weight

615.4 g/mol

AD

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids
Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds
Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates
Fine Chemicals Dyes and Pigments Organic Dyes
Fine Chemicals Surfactants Anionic Surfactants
Fine Chemicals Specialty Chemicals UV Stabilizers
Agricultural Chemicals Pesticides Herbicides
Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Density

1.74

SMILES

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CC(=O)Nc1cccc(c1)n2c(=O)n(C3CC3)c(=O)c4c(Nc5ccc(I)cc5F)n(C)c(=O)c(C)c24

InChI

InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)

InChIKey

LIRYPHYGHXZJBZ-UHFFFAOYSA-N

LogP

3.940120000000002

Topological Polar Surface Area

107.13 Ų

Hydrogen Bond Donor/Acceptor

2 / 9

Complexity

1090

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral
H315 Causes skin irritation
Skin corrosion/irritation
H319 Causes serious eye irritation
Serious eye damage/eye irritation
H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

  • N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide
  • Trametinib (GSK1120212)
  • C26H23FIN5O4
  • GSK1120212
  • GSK-1120212
  • GSK1120212 (JTP-74057)
  • N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide
  • N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin...
  • N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)
  • Trametinib
  • Trametinib (GSK1120212, GSK212, JTP-74057, Mekinist®)
  • Trametinib-D4
  • Trametinib-D6
  • JTP74057
  • JTP-74057
  • Mekinist
  • GSK 1120212
  • JTP 74057
  • GSK212
  • Trametinib (GSK1120212JTP 74057)
  • 33E86K87QN
  • AK174783
  • N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide
  • N-(3-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide

MDL Number

MFCD17215075

Customs Code

29339900

FAQ

What is N-(3-{3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide (CAS: 871700-17-3)?
N-(3-{3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide (CAS: 871700-17-3) is a complex organic compound featuring a pyrido[4,3-d]pyrimidinone core with substituents including a cyclopropyl group, 2-fluoro-4-iodophenylamino, and dimethyl groups. It is typically a solid at room temperature with limited solubility in water and is known for its potential in pharmaceutical research due to its structural complexity.

What are the main uses of N-(3-{3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide (CAS: 871700-17-3)?
This compound is primarily used in pharmaceutical research as a potential inhibitor for target enzymes, particularly in the development of antiviral and anticancer drugs. Its unique chemical structure makes it a valuable synthetic intermediate in drug discovery and chemical synthesis processes involving pyrimidine derivatives.

Is N-(3-{3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide (CAS: 871700-17-3) safe?
Safety data for this compound is limited, but as with many complex chemicals, it requires careful handling. Precautions include wearing protective gloves, goggles, and clothing to avoid skin contact or inhalation. It is classified as a hazardous substance under standard safety guidelines, and proper disposal should follow local regulations to ensure environmental and health protection.

How should N-(3-{3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide (CAS: 871700-17-3) be stored?
This compound should be stored in a cool, dry, and dark place, preferably at 2-8°C, in airtight containers to prevent moisture exposure. Avoid contact with light and ensure proper ventilation. Stability is maintained under controlled storage conditions, but long-term storage may require inert gas protection to preserve its chemical integrity.

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Supplier Information

N-(3-{3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide — Shanghai Yinxin Laboratory Equipment Co., Ltd.

Shanghai Yinxin Laboratory Equipment Co., Ltd.

CAS Number: 871700-17-3

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N-(3-{3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide — Beijing Bailingwei Technology Co., Ltd.

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N-(3-{3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide — Hubei Dahao Chemical Co., Ltd.

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