6-Methylindoline

Basic Information

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CAS Number

86911-82-2

Molecular Formula

C9H11N

Molecular Weight

133.19 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

SMILES

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CC1=CC2=C(C=C1)CCN2

InChI

InChI=1S/C9H11N/c1-7-2-3-8-4-5-10-9(8)6-7/h2-3,6,10H,4-5H2,1H3

InChIKey

GYHSHGUXLJLVAR-UHFFFAOYSA-N

LogP

1.9630199999999998

Topological Polar Surface Area

12.03 Å²

Hydrogen Bond Donor/Acceptor

1 / 1

Synonyms & References

English

6-Methylindoline
1H-INDOLE,2,3-DIHYDRO-6-METHYL-
6-Methyl-2,3-dihydro-1H-indole
6-Methyl-2,3-dihydro-1H-indole
1H-INDOLE,2,3-DIHYDRO-6-METHYL
2,3-dihydro-6-methyl-1H-indole
6-methyl-2,3-dihydroindole
7-methylindoline

MDL Number

MFCD07371640

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 6-Methylindoline (CAS: 86911-82-2)?

6-Methylindoline (CAS: 86911-82-2) is a crystalline compound with a molecular weight of approximately 130.18 g/mol. It is slightly soluble in water but soluble in organic solvents like ethanol and acetone. Chemically, it is known for its reactivity towards electrophilic aromatic substitution and nucleophilic substitution reactions. It is also relatively stable under normal conditions but should be stored in a cool, dark place to prevent degradation.

How is 6-Methylindoline (CAS: 86911-82-2) typically synthesized?

6-Methylindoline (CAS: 86911-82-2) is typically synthesized via an aromatic substitution reaction. Common methods include the Friedel-Crafts alkylation of indole with methyl halides using aluminum chloride as a catalyst. The reaction proceeds with good selectivity and yield, making it a practical method for industrial production.

What industries use 6-Methylindoline (CAS: 86911-82-2)?

6-Methylindoline (CAS: 86911-82-2) finds applications in the pharmaceutical industry, where it is used as an intermediate in the synthesis of various drugs. It is also utilized in the dye and pigment industry for the production of organic dyes. Additionally, it has potential uses in polymer chemistry for the development of new materials and in the electronics industry for semiconductor applications.

What precautions should be taken when handling 6-Methylindoline (CAS: 86911-82-2)?

When handling 6-Methylindoline (CAS: 86911-82-2), it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. It should be stored in a cool, well-ventilated area away from direct sunlight. In case of spills, use appropriate absorbents and follow local safety regulations for disposal. Always consult the Safety Data Sheet (SDS) for detailed handling and emergency procedures.