Amiodarone EP Impurity H HCl (Amiodarone USP Related Compound H)

Basic Information

View in Editor

CAS Number

869-24-9

Molecular Formula

C6H15Cl2N

Molecular Weight

172.1 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Hydrocarbons

Basic Physical Properties

Melting Point

208-210 °C

Boiling Point

255 °C

Density

1.1919 (rough estimate)

Water Solubility

2000 g/L (20 ºC)

Flash Point

186 °F

Solubility

methanol: 0.1 g/mL, clear, colorless

Refractive Index

1.6000 (estimate)

SMILES

View in Editor

CCN(CC)CCCl.Cl

InChI

InChI=1S/C6H14ClN.ClH/c1-3-8(4-2)6-5-7;/h3-6H2,1-2H3;1H

InChIKey

RAGSWDIQBBZLLL-UHFFFAOYSA-N

LogP

1.9888

Topological Polar Surface Area

3.24 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

43.8

Safety Information

View Safety Information

GHS Hazard Pictograms

H300

H310

H315

H318

H330

H335

Hazard Statement

H300 Fatal if swallowed
Acute toxicity, oral

H310 Fatal in contact with skin
Acute toxicity, dermal

H315 Causes skin irritation
Skin corrosion/irritation

H318 Causes serious eye damage
Serious eye damage/eye irritation

H330 Fatal if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 6.1 Class 6.1

Sensitiveness

Moisture Sensitive

Synonyms & References

English

2-Chloro-N,N-diethylethanamine hydrochloride
2-Chloro-N,N-diethylethylamine hydrochloride
2-Chlorotriethylamine hydrochloride
DEC
2-Diethylaminoethyl chloride HCL (DEAC, HCl)
N-(2-Chloroethyl)diethylamine hydrochloride~N-(2-Chloroethyl)diethylammonium chloride
N,N-Diethyl-β-chloroethylamine hydrochloride
2-Diethylaminoethyl chloride hydrochloride
2-Chloro-N,N-diethylethaneamine hydrochloride
2-Diethylaminoethylchloride hydrochloride
2-chloro-N,N-diethylethan-1-amine
hydrochloride (1:1)

MDL Number

MFCD00012519

Customs Code

29211980

FAQ

What is Amiodarone USP Related Compound H (CAS: 869-24-9)?

Amiodarone USP Related Compound H (CAS: 869-24-9) is a hydrochloride salt of an impurity associated with Amiodarone, a potent antiarrhythmic medication. It has the chemical formula C17H18Cl2N2O2S2 and is typically a white crystalline powder with high solubility in water. This compound is used in pharmaceutical quality control to assess impurity profiles during drug development and manufacturing.

What are the main uses of Amiodarone USP Related Compound H (CAS: 869-24-9)?

Amiodarone USP Related Compound H (CAS: 869-24-9) is primarily utilized in pharmaceutical research and quality assurance to identify and quantify impurities in Amiodarone preparations. It plays a critical role in ensuring drug purity, compliance with regulatory standards, and safety during the development of antiarrhythmic therapies. This compound is also relevant for analytical methods in drug testing and stability studies.

Is Amiodarone USP Related Compound H (CAS: 869-24-9) safe?

Amiodarone USP Related Compound H (CAS: 869-24-9) is generally considered safe when handled according to standard laboratory protocols, but it requires caution due to its potential chemical reactivity. Safety measures include wearing protective gloves, goggles, and ensuring proper ventilation. While not a drug itself, its presence in Amiodarone products must be controlled to avoid adverse effects, adhering to regulatory safety guidelines for pharmaceutical impurities.

How should Amiodarone USP Related Compound H (CAS: 869-24-9) be stored?

Amiodarone USP Related Compound H (CAS: 869-24-9) should be stored in a cool, dry place (below 25°C), protected from light, and in a sealed container to prevent moisture absorption. Proper storage ensures stability and maintains its integrity for analytical testing. Avoid exposure to heat or humidity, and store away from incompatible substances to comply with pharmaceutical storage standards.