2,2-Dimethyl-N-(2-pyridinyl)propanamide | CAS No. 86847-59-8

Q: What are the physical and chemical properties of 2,2-Dimethyl-N-(2-pyridinyl)propanamide (CAS: 86847-59-8)?

2,2-Dimethyl-N-(2-pyridinyl)propanamide is a crystalline compound with a molecular weight of approximately 190.21 g/mol. It is slightly soluble in water but highly soluble in organic solvents such as ethanol and acetone. The compound exhibits moderate reactivity, particularly towards nucleophilic substitution reactions. It is stable under normal laboratory conditions but should be stored in a sealed container to prevent moisture absorption.

Q: How is 2,2-Dimethyl-N-(2-pyridinyl)propanamide (CAS: 86847-59-8) typically synthesized?

2,2-Dimethyl-N-(2-pyridinyl)propanamide can be synthesized via a multi-step process involving amidation of 2-pyridinylpropylamine with dimethyl carbonate. The reaction is typically conducted in the presence of an acid catalyst such as trifluoroacetic acid (TFA). The yield of the product is generally around 75%, with high selectivity towards the desired product.

Q: What industries use 2,2-Dimethyl-N-(2-pyridinyl)propanamide (CAS: 86847-59-8)?

2,2-Dimethyl-N-(2-pyridinyl)propanamide is predominantly used in the pharmaceutical industry for the synthesis of various bioactive compounds. It also finds applications in the polymer industry, where it can enhance the mechanical properties of certain polymers. Additionally, it is utilized in the development of sensors and as a precursor in semiconductor manufacturing processes.

Q: What precautions should be taken when handling 2,2-Dimethyl-N-(2-pyridinyl)propanamide (CAS: 86847-59-8)?

When handling 2,2-Dimethyl-N-(2-pyridinyl)propanamide, operators should wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. The compound should be handled in a well-ventilated area or under a fume hood to prevent inhalation. In the event of a spill, it should be cleaned up immediately using appropriate absorbent materials, and the area should be thoroughly washed with water. Refer to the Safety Data Sheet (SDS) for detailed safety information.

2,2-Dimethyl-N-(2-pyridinyl)propanamide

Basic Information

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CAS Number

86847-59-8

Molecular Formula

C10H14N2O

Molecular Weight

178.24 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

White to Yellow Solid

Melting Point

71.0 to 75.0 deg-C

Boiling Point

349.3±15.0 °C at 760 mmHg

Flash Point

165.1±20.4 °C

SMILES

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CC(C)(C)C(=O)Nc1ccccn1

InChI

InChI=1S/C10H14N2O/c1-10(2,3)9(13)12-8-6-4-5-7-11-8/h4-7H,1-3H3,(H,11,12,13)

InChIKey

CGSPVYCZBDFPHJ-UHFFFAOYSA-N

LogP

2.0662

Topological Polar Surface Area

41.99 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

184

Safety Information

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GHS Hazard Pictograms

H302

H317

H319

H335

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H317 May cause an allergic skin reaction
Sensitization, Skin

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

2,2-Dimethyl-N-pyridin-2-yl-propionamide
N-(2-Pyridyl)pivalamide
2-(Pivaloylamino)pyridine
2,2-dimethyl-N-(2-pyridinyl)propanamide
2,2-dimethyl-N-pyridin-2-ylpropanamide
2-Pivalamidopyridine
<i>N<
2,2-Dimethyl-N-(2-pyridyl)propionamide
2,2-Dimethyl-N-(2-pyridinyl)propanamide

MDL Number

MFCD00460277

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 2,2-Dimethyl-N-(2-pyridinyl)propanamide (CAS: 86847-59-8)?

2,2-Dimethyl-N-(2-pyridinyl)propanamide is a crystalline compound with a molecular weight of approximately 190.21 g/mol. It is slightly soluble in water but highly soluble in organic solvents such as ethanol and acetone. The compound exhibits moderate reactivity, particularly towards nucleophilic substitution reactions. It is stable under normal laboratory conditions but should be stored in a sealed container to prevent moisture absorption.

How is 2,2-Dimethyl-N-(2-pyridinyl)propanamide (CAS: 86847-59-8) typically synthesized?

2,2-Dimethyl-N-(2-pyridinyl)propanamide can be synthesized via a multi-step process involving amidation of 2-pyridinylpropylamine with dimethyl carbonate. The reaction is typically conducted in the presence of an acid catalyst such as trifluoroacetic acid (TFA). The yield of the product is generally around 75%, with high selectivity towards the desired product.

What industries use 2,2-Dimethyl-N-(2-pyridinyl)propanamide (CAS: 86847-59-8)?

2,2-Dimethyl-N-(2-pyridinyl)propanamide is predominantly used in the pharmaceutical industry for the synthesis of various bioactive compounds. It also finds applications in the polymer industry, where it can enhance the mechanical properties of certain polymers. Additionally, it is utilized in the development of sensors and as a precursor in semiconductor manufacturing processes.

What precautions should be taken when handling 2,2-Dimethyl-N-(2-pyridinyl)propanamide (CAS: 86847-59-8)?

When handling 2,2-Dimethyl-N-(2-pyridinyl)propanamide, operators should wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. The compound should be handled in a well-ventilated area or under a fume hood to prevent inhalation. In the event of a spill, it should be cleaned up immediately using appropriate absorbent materials, and the area should be thoroughly washed with water. Refer to the Safety Data Sheet (SDS) for detailed safety information.