Compound Q&A

How is 2,2-Dimethyl-N-(2-pyridinyl)propanamide (CAS: 86847-59-8) typically synthesized?

Answer

2,2-Dimethyl-N-(2-pyridinyl)propanamide
2,2-Dimethyl-N-(2-pyridinyl)propanamide can be synthesized via a multi-step process involving amidation of 2-pyridinylpropylamine with dimethyl carbonate. The reaction is typically conducted in the presence of an acid catalyst such as trifluoroacetic acid (TFA). The yield of the product is generally around 75%, with high selectivity towards the desired product.

About

CAS No 86847-59-8
English Name 2,2-Dimethyl-N-(2-pyridinyl)propanamide
Molecular Formula C10H14N2O
Molecular Weight 178.24 g/mol
SMILES CC(C)(C)C(=O)Nc1ccccn1
InChIKey CGSPVYCZBDFPHJ-UHFFFAOYSA-N
Last Updated: 2025-10-13 11:18

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