6-{4-[2-(1-Piperidinyl)ethoxy]phenyl}-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine

Basic Information

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CAS Number

866405-64-3

Molecular Formula

C24H25N5O

Molecular Weight

399.5 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Density

1.255

Solubility

DMSO: >2mg/mL (warmed)

Refractive Index

1.67

SMILES

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C1CCN(CC1)CCOc1ccc(cc1)c1cnc2n(c1)ncc2c1ccncc1

InChI

InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2

InChIKey

XHBVYDAKJHETMP-UHFFFAOYSA-N

LogP

4.323000000000003

Topological Polar Surface Area

55.55 Å²

Hydrogen Bond Donor/Acceptor

0 / 6

Complexity

514

Safety Information

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GHS Hazard Pictograms

H302

H312

H332

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H312 Harmful in contact with skin
Acute toxicity, dermal

H332 Harmful if inhaled
Acute toxicity, inhalation

Sensitiveness

对光及空气敏感

Synonyms & References

English

6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine
Dorsomorphin
6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
BML-275
Dorsomorphin (Compound C, BML-275)
Dorsomorphin dihydrochloride
Pyrazolo[1,5-a]pyrimidine,6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-
AMPK Inhibitor,Compound C
BML275
Compound C
AMPK Inhibitor
AMPK Inhibitor, Compound C
Dorsomorphin (Compound C)
4-(6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}pyrazolo[1,5-a]pyrimidin-3-yl)pyridine
6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine
Dorsomo
6-[4-(2-Piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine

MDL Number

MFCD08705402

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 6-{4-[2-(1-Piperidinyl)ethoxy]phenyl}-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine (CAS: 866405-64-3)?

6-{4-[2-(1-Piperidinyl)ethoxy]phenyl}-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine is a crystalline compound with a molecular weight of approximately 491.7 g/mol. It has low water solubility and moderate organic solubility. The compound exhibits good stability under normal conditions but may react with strong acids and bases. It is an effective inhibitor and shows promising properties in pharmaceutical and medical applications.

How is 6-{4-[2-(1-Piperidinyl)ethoxy]phenyl}-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine (CAS: 866405-64-3) typically synthesized?

6-{4-[2-(1-Piperidinyl)ethoxy]phenyl}-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine is typically synthesized via a multi-step process involving the synthesis of key intermediates, followed by coupling reactions. Common methods include Suzuki coupling and palladium catalysis, which provide high yields and good selectivity. Detailed procedures are available in academic journals and patents.

What industries use 6-{4-[2-(1-Piperidinyl)ethoxy]phenyl}-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine (CAS: 866405-64-3)?

6-{4-[2-(1-Piperidinyl)ethoxy]phenyl}-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine is widely used in the pharmaceutical industry due to its potential as an inhibitor. It also finds applications in the development of medical devices and in certain sensor technologies. Its use in polymer and semiconductor industries is more limited but is being explored for specific applications.

What precautions should be taken when handling 6-{4-[2-(1-Piperidinyl)ethoxy]phenyl}-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine (CAS: 866405-64-3)?

When handling 6-{4-[2-(1-Piperidinyl)ethoxy]phenyl}-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine, it is essential to wear personal protective equipment (PPE) such as gloves, goggles, and lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up using appropriate PPE and according to safety data sheet (SDS) guidelines. Ensure proper storage in a secure, well-ventilated area away from direct sunlight and heat sources.