ent-Rivaroxaban

Basic Information

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CAS Number

865479-71-6

Molecular Formula

C19H18ClN3O5S

Molecular Weight

435.88 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Density

1.460

SMILES

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O=C1OC(CN1c1ccc(cc1)N1CCOCC1=O)CNC(=O)c1ccc(s1)Cl

InChI

InChI=1S/C19H18ClN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)

InChIKey

KGFYHTZWPPHNLQ-UHFFFAOYSA-N

LogP

2.5199

Topological Polar Surface Area

88.18 Å²

Hydrogen Bond Donor/Acceptor

1 / 8

Complexity

645

Synonyms & References

English

2-Thiophenecarboxamide, 5-chloro-N-[[(5R)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl ]methyl]-
5-R-Rivaroxaban
2-Thiophenecarboxamide,5-chloro-N-[[(5R)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidiny...
BAY 59-7939
ent-Rivaroxaban
R-Rivaroxaban
(R)-Rivaroxaban
5-chloro-N-[[(5R)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl]thiophene-2-carboxamide
5-Chloro-N-({(5R)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide
5-chloro-N-{[(5R)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide
THI089
BDBM13001
(R)-Rivaroxaban, ent-Rivaroxaban
(R)-5-chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide

MDL Number

MFCD17171369

FAQ

What regulatory guidelines apply to ent-Rivaroxaban (CAS: 865479-71-6)?

Ent-Rivaroxaban (CAS: 865479-71-6) is subject to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) and REACH regulations in the European Union. It is also regulated by the FDA and EPA in the United States. Manufacturers and distributors are required to provide Material Safety Data Sheets (MSDS) and comply with local and international regulations regarding hazardous substances.

Are there alternatives to ent-Rivaroxaban (CAS: 865479-71-6) in synthesis?

Alternative reagents to ent-Rivaroxaban (CAS: 865479-71-6) include other direct thrombin inhibitors such as argatroban and dabigatran. In synthesis, chemists often explore isomers and analogs like ent-N-methyl rivaroxaban, which can serve as viable alternatives due to similar pharmacological properties.

What is the market or research trend for ent-Rivaroxaban (CAS: 865479-71-6)?

The market for ent-Rivaroxaban (CAS: 865479-71-6) continues to grow due to its efficacy in treating deep vein thrombosis and pulmonary embolism. Research trends focus on its potential in cardiology and hematology, as well as its role in cardiovascular risk reduction. Price trends indicate steady demand with slight fluctuations driven by clinical trial outcomes and new therapeutic indications.

How should waste containing ent-Rivaroxaban (CAS: 865479-71-6) be handled?

Waste containing ent-Rivaroxaban (CAS: 865479-71-6) should be collected in appropriate containers labeled with the chemical name and CAS number. It should be kept in a secure area to prevent environmental contamination. For disposal, engage professional hazardous waste management services to ensure compliance with local and international regulations. Proper incineration or landfilling methods should be utilized to minimize environmental impact.