Benazepril HCl

Basic Information

View in Editor

CAS Number

86541-74-4

Molecular Formula

C24H29ClN2O5

Molecular Weight

460.96 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Powder

Melting Point

183°C

Boiling Point

No data available

Flash Point

No data available

Solubility

DMSO: ~34 mg/mL, soluble

Vapor Pressure

No data available

Specific Rotation

-137° (C=1,EtOH)

SMILES

View in Editor

Cl.CCOC(=O)[C@H](CCc1ccccc1)N[C@H]2CCc3ccccc3N(CC(=O)O)C2=O

InChI

InChI=1S/C24H28N2O5.ClH/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28;/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28);1H/t19-,20-;/m0./s1

InChIKey

VPSRQEHTHIMDQM-FKLPMGAJSA-N

LogP

2.9949000000000012

Topological Polar Surface Area

95.94 Å²

Hydrogen Bond Donor/Acceptor

2 / 7

Complexity

619

Safety Information

View Safety Information

GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

Benazepril HCL
benazepril hydrochloride
2-[(3S)-3-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid,hydrochloride
CGS14824A
CGS-14824A
(3S)-3-[(1S)-1-Ethoxycarbonyl-3-phenylpropyl]amino-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic Acid Hydrochloride
{(3S)-3-[(1S)-1-Ethoxycarbonyl-3-phenylpropylamino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-1-yl}acetic acid hydrochloride
Lotensin
Cibacene
Cibacen
Briem
Zinadril
Tensanil
Labopol
Cibace
Cibacen CHF
Benazepril (hydrochloride)
CGS 14824A HCl
CGS 14824A
N1SN99T69T
DSSTox_CID_25922
DSSTox_RID_81225
DSSTox_GSID_45922
(3S)-3-(((1S)-1-Carboxy-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid, 3-ethyl ester, monohydrochloride
C24H29ClN2O5
2-((S)-3-(((S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino)-2-oxo-2,3,4,5-
Benazeprilhydrochloride
Benazepril hydrochloride
2-((S)-3-(((S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetic acid
hydrochloride (1:1)

MDL Number

MFCD00895734

Customs Code

2933990090

FAQ

What is Benazepril HCl (CAS: 86541-74-4)?

Benazepril HCl (CAS: 86541-74-4) is an angiotensin-converting enzyme (ACE) inhibitor with the chemical formula C18H25N3O5S·HCl. It is a white crystalline powder, soluble in water, and commonly used in pharmaceuticals for its antihypertensive properties. This compound works by blocking the conversion of angiotensin I to angiotensin II, reducing blood pressure and improving cardiovascular health.

What are the main uses of Benazepril HCl (CAS: 86541-74-4)?

Benazepril HCl (CAS: 86541-74-4) is primarily used as a prescription medication for treating hypertension (high blood pressure) and heart failure. It is also prescribed to improve survival rates after myocardial infarction (heart attack). In the pharmaceutical industry, it serves as a key active ingredient in ACE inhibitor drugs, aiding in managing cardiovascular diseases and reducing proteinuria in kidney disorders.

Is Benazepril HCl (CAS: 86541-74-4) safe?

Benazepril HCl (CAS: 86541-74-4) is generally safe when used as directed, but it may cause side effects such as dizziness, cough, or hyperkalemia in some patients. Safety standards include FDA approval for hypertension treatment and adherence to OSHA guidelines for handling. Precautions involve avoiding use in patients with a history of angioedema and consulting healthcare professionals for proper dosage and monitoring.

How should Benazepril HCl (CAS: 86541-74-4) be stored?

Benazepril HCl (CAS: 86541-74-4) should be stored in a cool, dry place (15-30°C), protected from moisture and light. It is stable under these conditions when kept in airtight containers. Avoid exposure to high humidity or extreme temperatures to maintain efficacy and prevent degradation of the compound.