Vincaleukoblastine

Basic Information

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CAS Number

865-21-4

Molecular Formula

C46H58N4O9

Molecular Weight

810.99 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Powder

Melting Point

211-216°C

Boiling Point

755.65°C (rough estimate)

Density

1.1325 (rough estimate)

Solubility

ODORLESS & HYGROSCOPIC; WHITE TO SLIGHTLY YELLOW, AMORPHOUS OR CRYSTALLINE POWDER; FREELY SOL IN WATER /VINBLASTINE SULFATE/

Refractive Index

1.6000 (estimate)

Vapor Pressure

1.03X10-27 mm Hg at 25 °C (est)

Specific Rotation

-32° (c=0.88, MeOH)

SMILES

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CC[C@@]1(C[C@H]2C[C@@](c3c(c4ccccc4[nH]3)CCN(C2)C1)(c5cc6c(cc5OC)N([C@@H]7[C@]68CCN9[C@H]8[C@@](C=CC9)([C@H]([C@@]7(C(=O)OC)O)OC(=O)C)CC)C)C(=O)OC)O

InChI

InChI=1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1

InChIKey

JXLYSJRDGCGARV-CFWMRBGOSA-N

LogP

3.990900000000004

pKa

5.4, 7.4(at 25℃)

Topological Polar Surface Area

154.1 Å²

Hydrogen Bond Donor/Acceptor

3 / 13

Complexity

1700

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 6.1(a) Class 6.1(a)

Synonyms & References

English

vinblastine
VINBLASTINE SULFATE(RG)
[3aR-[3aa,4b,5b,5ab,9(3R*,5S*,7R*,9S*),10bR*,13aa]]-Methyl 4-(acetyloxy)-3a-ethyl-9-[5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6-methyl-1H-indolizino[8,1-cd]carbazole-5-carboxylate
1H-Indolizino[8,1-cd]carbazole, vincaleukoblastine deriv.
1H-Indolizino[8,1-cd]carbazole-5-carboxylic acid, 4-(acetyloxy)-3a-ethyl-9-[5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6-methyl-, methyl ester, [3aR-[3aa,4b,5b,5ab,9(3R*,5S*,7R*,9S*),10bR*,13aa]]-
2H-3,7-Methanoazacycloundecino[5,4-b]indole, vincaleukoblastine deriv.
Rozevin
C46H58N4O9
Vinblastine-d3
Vinblastine-d6 Sulfate
vinblastine sulfuric acid salt
Vinblastine sulphate
Vinblastine,Vincaleukoblastine
Vincaleucoblastin
Vincaleucoblastine
Vincaleukoblastine
Vincoblastine

MDL Number

MFCD05662370

FAQ

What is Vincaleukoblastine (CAS: 865-21-4)?

Vincaleukoblastine, with the CAS number 865-21-4, is a synthetic compound belonging to the class of vinca alkaloids. It is known for its antitumor properties and is used in cancer research. The chemical formula of Vincaleukoblastine is C20H26N2O4, and it exhibits solubility in organic solvents. It is a derivative of vincamine and has been studied for its potential in inhibiting cell division.

What are the main uses of Vincaleukoblastine (CAS: 865-21-4)?

Vincaleukoblastine is primarily used in pharmaceutical research for its anticancer properties. It has been investigated as a potential therapeutic agent for various malignancies, including leukemia. Additionally, it is used in biochemical studies to explore mechanisms of cell growth inhibition and may find applications in drug development. Its use in food or industrial sectors is limited due to its specialized nature.

Is Vincaleukoblastine (CAS: 865-21-4) safe?

Vincaleukoblastine is generally considered safe when used under controlled conditions and appropriate handling. However, as with many chemotherapeutic agents, it may have toxic effects if misused. It is important to follow safety guidelines, use personal protective equipment, and handle it in a well-ventilated area. Regulatory standards ensure its safe use in research and pharmaceutical settings.

How should Vincaleukoblastine (CAS: 865-21-4) be stored?

Vincaleukoblastine should be stored in a cool, dry, and dark place, away from moisture and direct light. It is typically kept in a tightly sealed container at a temperature below 25°C. Proper storage conditions are crucial to maintain its stability and potency. Avoid exposure to air and keep it in a secure location to prevent contamination or accidental handling.