Azilsartan medoxomil

Basic Information

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CAS Number

863031-21-4

Molecular Formula

C30H24N4O8

Molecular Weight

568.54 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Boiling Point

748.0±70.0°C at 760 mmHg

Density

1.45

SMILES

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CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NOC(=O)N5)C(=O)OCC6=C(OC(=O)O6)C

InChI

InChI=1S/C30H24N4O8/c1-3-38-28-31-23-10-6-9-22(27(35)39-16-24-17(2)40-30(37)41-24)25(23)34(28)15-18-11-13-19(14-12-18)20-7-4-5-8-21(20)26-32-29(36)42-33-26/h4-14H,3,15-16H2,1-2H3,(H,32,33,36)

InChIKey

QJFSABGVXDWMIW-UHFFFAOYSA-N

LogP

4.705220000000004

Topological Polar Surface Area

155.58999999999997 Å²

Hydrogen Bond Donor/Acceptor

1 / 12

Complexity

1100

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Azilsartan medoxomil
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-3-[[4-[2-(5-oxo-4H-1,2,4-+oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
Azilsartan Kamedoxomil
TAK491
TAK-491
Edarbi
TAK 491
Azilsartan (medoxomil)
LL0G25K7I2
1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl]-2-ethoxy-1H-benziMidazole-7-carboxylic acid (5-Methyl-2-oxo-1,3-dioxol-4-yl)Methyl ester
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1-benzimidazole-7-carboxylate
Azilsartan medoxomil [USAN:IN
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
CHEMBL2028661
SB19560
EN300-7358109
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-3-[[4-[2-(5-oxo-2H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
HMS3651H18
SW219494-1
BRD-K25723200-001-02-7
azilsartanum medoxomilum
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate
863031-21-4
D08067
AZILSARTAN MEDOXOMIL
AB01566809_01
Azilsartan medoxomil [USAN:INN]
QJFSABGVXDWMIW-UHFFFAOYSA-N
1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl
Q1087888
AS-57282

MDL Number

MFCD19443688

FAQ

What is Azilsartan medoxomil (CAS: 863031-21-4)?

Azilsartan medoxomil is an angiotensin II receptor blocker (ARB) used in the treatment of hypertension. It has the chemical formula C22H26N4O5S and is known for its high solubility in water, making it suitable for oral administration. The compound is a prodrug of azilsartan, which is metabolized in the body to exert its antihypertensive effects.

What are the main uses of Azilsartan medoxomil (CAS: 863031-21-4)?

Azilsartan medoxomil is primarily used as a medication for managing high blood pressure (hypertension). It is also prescribed for patients with type 2 diabetes to reduce the risk of cardiovascular events. The compound is valued in pharmaceutical applications for its efficacy, safety profile, and ability to improve patient compliance due to its oral formulation.

Is Azilsartan medoxomil (CAS: 863031-21-4) safe?

Azilsartan medoxomil is generally considered safe when used as directed. It has been evaluated for toxicity and is approved by regulatory agencies for its therapeutic use. However, proper handling and storage are essential to prevent degradation. Protective measures, such as using gloves and avoiding direct skin contact, are recommended during preparation and administration.

How should Azilsartan medoxomil (CAS: 863031-21-4) be stored?

Azilsartan medoxomil should be stored in a cool, dry place away from direct light. It is typically kept at a temperature range of 15°C to 30°C (59°F to 86°F) and in airtight containers to maintain its stability and potency. Avoid exposure to moisture and humidity to ensure long-term shelf life and effectiveness.