6-Methoxy-2-pyridinecarbohydrazide

Basic Information

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CAS Number

855784-42-8

Molecular Formula

C7H9N3O2

Molecular Weight

167.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

155-156°C

Density

1.2±0.1 g/cm3

Refractive Index

1.562

SMILES

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NNC(=O)c1cccc(n1)OC

InChI

InChI=1S/C7H9N3O2/c1-12-6-4-2-3-5(9-6)7(11)10-8/h2-4H,8H2,1H3,(H,10,11)

InChIKey

GMZSCQXNOIDMCL-UHFFFAOYSA-N

LogP

-0.30630000000000046

Topological Polar Surface Area

77.24 Å²

Hydrogen Bond Donor/Acceptor

3 / 5

Complexity

163

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

2-Pyridinecarboxylicacid, 6-methoxy-, hydrazide
6-Methoxypicolinohydrazide
6-methoxypyridine-2-carbohydrazide
6-Methoxy-pyridine-2-carboxylic acid hydrazide
6-methoxy-2-pyridinecarbohydrazide
6-methoxypyridin-2-carbohydrazide

MDL Number

MFCD08235125

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 6-Methoxy-2-pyridinecarbohydrazide (CAS: 855784-42-8)?

6-Methoxy-2-pyridinecarbohydrazide is a crystalline solid with a molecular weight of approximately 203.16 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol and acetone. The compound exhibits moderate reactivity, particularly towards nucleophiles, and can undergo substitution reactions under basic conditions.

How is 6-Methoxy-2-pyridinecarbohydrazide (CAS: 855784-42-8) typically synthesized?

6-Methoxy-2-pyridinecarbohydrazide is often synthesized via the condensation of 2-pyridinecarboxaldehyde with hydrazine hydrate followed by methylation of the resulting intermediate. Common catalysts include sodium methoxide, and the overall process provides good yield (around 75-85%) with good selectivity.

What industries use 6-Methoxy-2-pyridinecarbohydrazide (CAS: 855784-42-8)?

6-Methoxy-2-pyridinecarbohydrazide has applications in the pharmaceutical industry for its potential use as a precursor in the synthesis of bioactive compounds. It is also used in the polymer industry for the preparation of functionalized polymers and in the sensor industry for the development of gas sensors.

What precautions should be taken when handling 6-Methoxy-2-pyridinecarbohydrazide (CAS: 855784-42-8)?

Proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn when handling 6-Methoxy-2-pyridinecarbohydrazide. It should be stored in a closed container in a well-ventilated area. If a spill occurs, it should be cleaned up using appropriate absorbent materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.