N-{4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl}-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide

Basic Information

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CAS Number

849217-68-1

Molecular Formula

C28H24FN3O5

Molecular Weight

501.51 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Powder

Density

1.396

SMILES

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COc1cc2c(ccnc2cc1OC)Oc1ccc(cc1)NC(=O)C1(CC1)C(=O)Nc1ccc(cc1)F

InChI

InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)

InChIKey

ONIQOQHATWINJY-UHFFFAOYSA-N

LogP

5.5408000000000035

Topological Polar Surface Area

98.78 Å²

Hydrogen Bond Donor/Acceptor

2 / 8

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H320 Causes eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

XL184
Cabozantinib (XL184, BMS-907351)
1,1-Cyclopropanedicarboxamide,N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-
1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
C28H24FN3O5
Cabozantinib
Cabozantinib (XL184,BMS 907351,Cometriq®)
Cabozantinib S-malate
Cabozantinib, XL184
N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
XL-180
XL-184
XL184 Cabozantinib
[14C]-Cabozantinib
BMS907351
BMS-907351
Cometriq
cyclopropane-1,1-dicarboxylic acid [4-(6,7-dimethoxy-quinoline-4-yloxy)-phenyl]-amide (4-fluoro-phenyl)-amide
N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
Cabozantinib Impurity
N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

MDL Number

MFCD20926324

Customs Code

2933499090

FAQ

What is N-{4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl}-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (CAS: 849217-68-1)?

N-{4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl}-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (CAS: 849217-68-1) is a complex organic compound containing a quinoline ring substituted with methoxy groups and a fluorophenyl group. It is a white to off-white solid with high molecular weight and exhibits moderate solubility in polar solvents. The compound is known for its structural complexity and potential applications in medicinal chemistry.

What are the main uses of N-{4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl}-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (CAS: 849217-68-1)?

This compound is primarily used in pharmaceutical research as a potential lead molecule for drug development. It may be explored for its biological activities, including anti-inflammatory or antitumor properties. Additionally, it is used in organic synthesis as a building block for more complex chemical structures.

Is N-{4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl}-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (CAS: 849217-68-1) safe?

Safety data for this compound is limited, but it is generally considered to have moderate toxicity based on its chemical structure. Precautions include wearing protective gloves, goggles, and lab coats when handling. It should be stored in a well-ventilated area and handled with care to avoid exposure. Always follow appropriate safety standards when working with this substance.

How should N-{4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl}-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (CAS: 849217-68-1) be stored?

This compound should be stored in a cool, dry place away from direct light. It is best kept in a sealed, airtight container to prevent moisture absorption. Storage at temperatures below 25°C is recommended to maintain stability. Avoid exposure to air and light to prevent degradation.